Administration of Oral Contraceptives at Different Times of the Follicular Phase of the Menstrual Cycle

Tracking Information
First Submitted Date ICMJE	September 12, 2005
First Posted Date ICMJE	September 20, 2005
Last Update Posted Date	November 28, 2016
Study Start Date ICMJE	February 2002
Primary Completion Date	Not Provided
Current Primary Outcome Measures ICMJE; (submitted: September 12, 2005)	follicle growth; ovulation/anovulation; estradiol concentration; LH concentration
Original Primary Outcome Measures ICMJE	Same as current
Change History	Complete list of historical versions of study NCT00204438 on ClinicalTrials.gov Archive Site
Current Secondary Outcome Measures ICMJE; (submitted: September 12, 2005)	endometrial development
Original Secondary Outcome Measures ICMJE	Same as current
Current Other Outcome Measures ICMJE	Not Provided
Original Other Outcome Measures ICMJE	Not Provided
Descriptive Information
Brief Title ICMJE	Administration of Oral Contraceptives at Different Times of the Follicular Phase of the Menstrual Cycle
Official Title ICMJE	Follicular Profiles After Administration of Oral Contraceptives at Different Times of the Follicular Phase of the Menstrual Cycle
Brief Summary	We hypothesize that administration of OCs at varying follicular diameters will provide an appropriate model for the study of follicular atresia in women. Clinically, we hypothesize that the administration on OCs at different stages of the follicular phase will result in markedly different patterns of follicular development and/or atresia.
Detailed Description	This study is a single-centre, randomized, open-label, double-controlled protocol to study the patterns of ovarian follicular growth and regression in women administered 0.15mg desogestrel /0.03mg ethinyl estradiol at different stages of the follicular phase of the menstrual cycle. We tracked the growth and regression of dominant follicles after administration of OC by means of highly sophisticated transvaginal ultrasonography and computerized image analysis techniques. The extremely high resolution ultrasonography of the ovarian follicles and the computer-assisted image analysis are unique to the Women's Health Imaging Research Laboratory (WHIRL) at the University of Saskatchewan. The synergyne (© R.A. Pierson) image analysis program was developed in the WHIRL and has the ability to allow assessment of the physiologic status of follicles as small as 6 to 10 mm. This unique protocol will allow us to characterize patterns of follicular growth and atresia under the suppressive effects of oral contraception, as well as the assessment of anovulatory follicles which may develop when OCs are administered at advanced stages of follicular development. The working hypothesis is that the administration of monophasic OCs prior to and during the time of physiologic selection of the dominant follicle will prevent the development of an ovulatory follicle (selection occurs when the dominant follicle reaches 10mm [Baerwald & Pierson, unpublished data]). In addition, we hypothesize that administration of OCs after selection of the dominant follicle, at more advanced stages of follicular development will result in 1 of 4 scenarios: 1.) Ovulation of the dominant follicle, 2.) Regression of the dominant follicle, 3). Formation of a Hemorrhagic Anovulatory follicle (HAF) or Luteinized Unruptured Follicle (LUF), or 4.) Formation of a follicular cyst. We hypothesize that atresia of dominant follicles and formation of anovulatory follicular structures will be associated with limited endometrial development. In testing these hypotheses, we will determine if OCs can safely and effectively be administered at any time during the follicular phase of the menstrual cycle. This study will evaluate the ovarian and uterine responses to administration of a combined dose of 0.15mg desogestrel /0.03mg ethinyl estradiol at 1 of 3 different stages of the follicular phase of the menstrual cycle. The objectives of the trial are to: Develop new and more user-friendly administration schemes for OC use;; Use the administration of OCs at different stages of follicular development in women as a model for studying follicular atresia;; Assess the differences in kinetics, physiologic status (state of viability or atresia), and ultrasonographic image attributes of follicles which grow, regress, ovulate, or form anovulatory follicular structures after the administration of exogenous steroid hormones;; Assess endometrial response to ovarian suppression by ultrasonographic evaluation of endometrial thickness and endometrial pattern. After screening measurements confirm subject eligibility, subjects will be randomized to initiate OC therapy at one of three different times of the menstrual cycle: Experimental Group #1: receives OCs when the dominant follicle reaches 10mm Experimental Group #2: receives OCs when the dominant follicle reaches 14mm Experimental Group #3: receives OCs when the dominant follicle reaches 18mm Fifteen women will be randomized to each of the 3 experimental groups in a stratified design scheme. Data collected from an ongoing OC trial (BMC# 2000-169) will serve as OC control data (n=15). Data collected from a previous study (BMC# 1988-80) will serve as natural cycle control data (n=60).
Study Type ICMJE	Interventional
Study Phase	Not Applicable
Study Design ICMJE	Allocation: Randomized; Intervention Model: Parallel Assignment; Masking: None (Open Label); Primary Purpose: Treatment
Condition ICMJE	Contraception
Intervention ICMJE	Drug: 0.15mg desogestrel /0.03mg ethinyl estradiol
Study Arms	Not Provided
Publications *	Baerwald AR, Adams GP, Pierson RA. A new model for ovarian follicular development during the human menstrual cycle. Fertil Steril. 2003 Jul;80(1):116-22.; Baerwald AR, Adams GP, Pierson RA. Characterization of ovarian follicular wave dynamics in women. Biol Reprod. 2003 Sep;69(3):1023-31. Epub 2003 May 14.; Pierson RA, Archer DF, Moreau M, Shangold GA, Fisher AC, Creasy GW. Ortho Evra/Evra versus oral contraceptives: follicular development and ovulation in normal cycles and after an intentional dosing error. Fertil Steril. 2003 Jul;80(1):34-42.
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
Recruitment Information
Recruitment Status ICMJE	Completed
Enrollment ICMJE; (submitted: September 12, 2005)	45
Original Enrollment ICMJE	Same as current
Study Completion Date	December 2002
Primary Completion Date	Not Provided
Eligibility Criteria ICMJE	Inclusion Criteria: Female volunteers of childbearing potential;; Are first time users of OCs or have discontinued OCs at least 1 month prior to study entry;; Aged between 18 and 35 years (extremes included);; Normal body mass index (18-38);; Has signed informed consent form;; Is in good health as confirmed by medical history, physical examination, and PAP smear or colposcopy within the past 12 months with normal results. Exclusion Criteria: Any contraindication for oral contraceptive use;; Irregular menstrual cycles; Ultrasonographic evidence of ovarian dysfunction, such as Polycystic Ovary Syndrome (PCOS);; Pregnancy (suspected or diagnosed) or lactation;; Use of disallowed concomitant therapy;; History or suspicion of drug or alcohol abuse;; Participation in an investigational drug trial within the 30 days prior to selection;; Exhibits a disorder that is a contraindication to steroid hormonal therapy, including, for example, the following conditions:; History of, or actual, thrombophlebitis or thromboembolic disorders;; History of, or actual, cerebrovascular disorders;; History of, or actual, myocardial infarction or coronary artery disease;; Acute liver disease;; History of, or actual, benign or malignant liver tumors;; Known, or suspected, carcinoma of the breast;; Known, or suspected, estrogen-dependent neoplasia;; Undiagnosed abnormal vaginal bleeding;; Any ocular lesion arising from opthalmic vascular disease, such as partial or complete loss of vision or defect in visual fields.; Latex allergy.
Sex/Gender	Sexes Eligible for Study: Female
Ages	18 Years to 35 Years (Adult)
Accepts Healthy Volunteers	Yes
Contacts ICMJE	Contact information is only displayed when the study is recruiting subjects
Listed Location Countries ICMJE	Canada
Removed Location Countries
Administrative Information
NCT Number ICMJE	NCT00204438
Other Study ID Numbers ICMJE	BMC 2001-249; CIHR MOP - 11489
Has Data Monitoring Committee	Not Provided
U.S. FDA-regulated Product	Not Provided
IPD Sharing Statement	Not Provided
Responsible Party	Roger Pierson, University of Saskatchewan
Study Sponsor ICMJE	University of Saskatchewan
Collaborators ICMJE	Canadian Institutes of Health Research (CIHR)
Investigators ICMJE	Principal Investigator: Roger A Pierson, MS PhD University of Saskatchewan
PRS Account	University of Saskatchewan
Verification Date	November 2016
ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP