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Efficacy of Zinc in the Treatment of Pneumonia

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00198666
First Posted: September 20, 2005
Last Update Posted: January 12, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Mathuram Santosham, Johns Hopkins Bloomberg School of Public Health
September 12, 2005
September 20, 2005
January 12, 2015
September 2003
August 2004   (Final data collection date for primary outcome measure)
Duration of severe symptoms [ Time Frame: 2 years ]
Duration of severe symptoms
Complete list of historical versions of study NCT00198666 on ClinicalTrials.gov Archive Site
Time to recovery from severe pneumonia [ Time Frame: 2 years ]
Time to recovery from severe pneumonia
Not Provided
Not Provided
 
Efficacy of Zinc in the Treatment of Pneumonia
Efficacy of Zinc in the Treatment of Pneumonia in Hospitalized Children Less Than 2 Years of Age
This study is designed to evaluate the efficacy of zinc supplementation in the treatment of children under the age of two years who have been hospitalized with severe pneumonia.
This study was a randomized, double-blind, placebo-controlled clinical trial conducted between September 2003 and August 2004 at the Christian Medical College (CMC) Hospital in Vellore, India. CMC Hospital is a large teaching hospital and medical center that is accessed directly by the population of Vellore and adjoining districts and by referrals from local medical practitioners.
Interventional
Not Provided
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Investigator)
Primary Purpose: Treatment
Pneumonia
Drug: Zinc
Elemental Zinc
  • Experimental: Treatment
    Children with severe pneumonia were randomly assigned to receive supplementation with elemental zinc.
    Intervention: Drug: Zinc
  • No Intervention: Control
    Children with severe pneumonia were randomly assigned to receive supplementation with placebo tablets.
Coles CL, Bose A, Moses PD, Mathew L, Agarwal I, Mammen T, Santosham M. Infectious etiology modifies the treatment effect of zinc in severe pneumonia. Am J Clin Nutr. 2007 Aug;86(2):397-403.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
299
August 2004
August 2004   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • children under two years old hospitalized with Pneumonia

Exclusion Criteria:

  • healthy children
Sexes Eligible for Study: All
up to 23 Months   (Child)
No
Contact information is only displayed when the study is recruiting subjects
Not Provided
 
 
NCT00198666
H.22.03.01.06.A2
No
Not Provided
Not Provided
Mathuram Santosham, Johns Hopkins Bloomberg School of Public Health
Johns Hopkins Bloomberg School of Public Health
Not Provided
Principal Investigator: Mathuram Santosham, MD Johns Hopkins Bloomberg School of Public Health
Johns Hopkins Bloomberg School of Public Health
January 2015

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP