Cardiovascular Risk Factors in Overweight Adolescents

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00184236
Recruitment Status : Completed
First Posted : September 16, 2005
Last Update Posted : March 30, 2017
St. Olavs Hospital
Information provided by (Responsible Party):
Norwegian University of Science and Technology

September 13, 2005
September 16, 2005
March 30, 2017
February 2005
February 2008   (Final data collection date for primary outcome measure)
VO2max change [ Time Frame: 3 months and 12 months ]
maximal oxygen uptake change
Cardiovascular risk factors; aerobic capacity, endothelial function, fatness, diverse blood markers ect.
Complete list of historical versions of study NCT00184236 on Archive Site
  • Cardiovascular risk factors [ Time Frame: 2 years ]
  • endothelial function change [ Time Frame: 3 months and 12 months ]
    measured as FMD (flow-mediated dilution) using high-resolution vascular ultrasound
Cardiovascular risk factors after 2 years follow up.
Not Provided
Not Provided
Cardiovascular Risk Factors in Overweight Adolescents
Aerobic Interval Training Reduces Cardiovascular Risk Factors More Than a Multitreatment Approach in Overweight Adolescents
The aim of the present study was to determine the effects of either a multidisciplinary approach or intensity-controlled interval training on cardiovascular risk factors in overweight adolescents.
Several approaches have been used to improve cardiovascular health status and quality of life in obese children and adolescents, without coming to a consensus decision. Recently, a few studies have determined the effects of exercise training and diet on endothelial function in overweight and obese children and adolescents. The main findings are that only a moderate amount of exercise training and diet changes improves or restores endothelial function. It is difficult, however, to asses the separate effects of the training and diet, particularly because none of the studies have used a homogenous exercise training regimen. Unanimously, better, but affordable prevention and treatment strategies to improve wide-scale health outcome are called upon to slow down the current epidemic of overweight. It is now well established that physical activity reduces, but does not currently prevent the epidemic of obesity from either reaching global proportions or taxing public health and economy. Despite the recent advances in understanding the responsible biology of improved cardiovascular health with exercise training, several lines of research questions are still unresolved. For instance, the optimal program, e.g. when to initiate, whom to prescribe exercise to, which exercise-intensity is required, and the actual design of the treatment program, remain by far yet to determine.
Not Applicable
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Treatment
  • Overweight
  • Obesity
  • Behavioral: Multitreatment approach
    12 months regimen consisting of group meetings every 2 weeks involving a physician, psychologist, physiotherapist and clinical nutritional physiologist. 21 h treatment during the first 3 months: 3 activity sessions (3 h) and 3 group conversations (4 h). Attendance inclusion criterium was set to minimum of 80%
    Other Name: multidisciplinary approach
  • Behavioral: Aerobic interval training
    Walking/running 'uphill' on a treadmill twice a week for 3 months. 10 min warming-up at 70% of Hfmax before performing 4x4 intervals at 90-95% of Hfmax. 3 min active recovery at 70% of Hfmax between each interval. 5 min cool-down period, giving a total of 40 min.
  • Active Comparator: Aerobic interval training
    Aerobic interval training (AIT)
    Intervention: Behavioral: Aerobic interval training
  • Active Comparator: Multitreatment approach
    multitreatment approach (MTG)
    Intervention: Behavioral: Multitreatment approach

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
May 2008
February 2008   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Overweight and obese adolescents in the Trondheim area, referred to medical treatment at St. Olav's Hospital

Exclusion Criteria:

  • Any coexisting medical illnesses
Sexes Eligible for Study: All
13 Years to 16 Years   (Child)
Contact information is only displayed when the study is recruiting subjects
Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Plan to Share IPD: No
Norwegian University of Science and Technology
Norwegian University of Science and Technology
St. Olavs Hospital
Study Chair: Ulrik Wisløff, PhD prof Norwegian University of Science and Technology
Norwegian University of Science and Technology
March 2017

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP