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Pharmacokinetics of Curcumin in Healthy Volunteers

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00181662
First Posted: September 16, 2005
Last Update Posted: April 4, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Massachusetts General Hospital
September 12, 2005
September 16, 2005
April 4, 2007
August 2005
Not Provided
Curcumin pharmacology
Same as current
Complete list of historical versions of study NCT00181662 on ClinicalTrials.gov Archive Site
  • Interactions between piperine and curcumin
  • Interactions between silybin and curcumin
Same as current
Not Provided
Not Provided
 
Pharmacokinetics of Curcumin in Healthy Volunteers
Evaluation of Naturally Occurring Inhibitors of UDP-Glucuronyltransferase on the Oral Bioavailability of Curcumin in Normal Healthy Volunteers
This study looks to describe the pharmacokinetics of curcumin delivered as a single oral dose in healthy female volunteers. The impact of piperine and silybin on the pharmacokinetics of curcumin is also studied.
Healthy volunteers are seen on three separate visits and receive 4 gm of curcumin as a single oral dose either alone or with piperine or with silybin. Serial timed blood draws then are collected for pharmacokinetic analysis.
Interventional
Not Provided
Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Healthy
Drug: Curcumin
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
6
Not Provided
Not Provided

Inclusion Criteria:

  • Healthy volunteer
  • On no medications except for birth control pills
  • Signed informed consent

Exclusion Criteria:

  • Pregnant
  • Comorbid disease
Sexes Eligible for Study: Female
18 Years and older   (Adult, Senior)
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
 
NCT00181662
2005P-000650
P50CA105009-01 ( U.S. NIH Grant/Contract )
Not Provided
Not Provided
Not Provided
Not Provided
Massachusetts General Hospital
Not Provided
Principal Investigator: Michael Seiden, M.D., Ph.D. Massachusetts General Hospital
Massachusetts General Hospital
April 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP