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Induction of Cytokines in Human Monocytes by SARS-CoV in Adults and Children

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified August 2005 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00173563
First Posted: September 15, 2005
Last Update Posted: December 3, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
National Science Council, Taiwan
Information provided by:
National Taiwan University Hospital
September 12, 2005
September 15, 2005
December 3, 2007
January 2005
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Complete list of historical versions of study NCT00173563 on ClinicalTrials.gov Archive Site
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Induction of Cytokines in Human Monocytes by SARS-CoV in Adults and Children
Induction of Cytokines in Human Monocytes by SARS-CoV in Adults and Children

Severe acute respiratory syndrome (SARS) is a new emerging infectious disease. Its pathogen is a newly discovered coronavirus (SARS-CoV). The clinical course can be classified to 3 stages: viral replication phase, hyperimmune reactive phase, and pulmonary destruction phase. Human monocyte plays a critical role in the initiation of immune response in defending the intracellular pathogens (eg viruses). Monocytes can engulf viruses and present the viral antigens in the major histocompatibility (MHC) molecule to the cell surface to initiate T lymphocyte response. Monocytes also secrete various cytokines to modulate immune response. SARS-CoV is a mutant of animal virus to cause human disease and is able to cause unusual severe respiratory illness. It is suggested the unusual severe disease is due to the intense immune reaction.

The investigators will harvest human monocytes from healthy adult and children blood donors. Monocytes would be cultured and infected by SARS-CoV. The change of viral load is monitored after infection. Cytokines secreted by monocytes after infection are also measured. The difference of monocyte cytokine secretion is compared between adults and children. The study is to verify the SARS-CoV infectivity of human monocytes and prove the unusual severity caused by SARS-CoV is related to viral-induced dysregulation of cytokine responses. The results may also clarify why adults tend to have a more severe illness compared with children.

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Observational
Time Perspective: Prospective
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Healthy
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Unknown status
10
September 2005
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Inclusion Criteria:

  • Healthy adults aged 20 to 50 years old
  • Healthy children aged 2 to 5 years old
Sexes Eligible for Study: All
2 Years to 50 Years   (Child, Adult)
Yes
Contact information is only displayed when the study is recruiting subjects
Taiwan
 
 
NCT00173563
9461700731
NSC92-2751-B-002-026-Y
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National Taiwan University Hospital
National Science Council, Taiwan
Principal Investigator: Luan-Yin Chang, MD, PhD Department of pediatrics, National Taiwan University Hospital
National Taiwan University Hospital
August 2005