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Genetics of Alpha Thalassemia in Israeli Ethnic Groups

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ClinicalTrials.gov Identifier: NCT00159029
Recruitment Status : Completed
First Posted : September 12, 2005
Last Update Posted : August 10, 2017
Sponsor:
Information provided by (Responsible Party):
Deborah Rund, Hadassah Medical Organization

September 9, 2005
September 12, 2005
August 10, 2017
April 1, 2004
July 1, 2017   (Final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT00159029 on ClinicalTrials.gov Archive Site
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Genetics of Alpha Thalassemia in Israeli Ethnic Groups
Haplotype Analysis of Alpha Globin Genes in Israeli Ethnic Groups

Alpha thalassemia causes mild anemia and is found in many ethnic groups. Usually it is found in regions where malaria is endemic. We have found that alpha thalassemia is common in Ashkenazim, whose countries of origin are in temperate climates.

We are analyzing the alpha globin genes of individuals of many ethnic groups and will compare to try to define the origin of thalassemia in these individuals of European extraction.

Alpha thalassemia causes mild anemia and is found in many ethnic groups. Usually it is found in regions where malaria is endemic. We have found that alpha thalassemia is common in Ashkenazim, whose countries of origin are in temperate climates.

We are analyzing the alpha globin polymorphisms to determine the haplotypes of individuals of many ethnic groups and will compare to try to define the origin of thalassemia in these individuals of European extraction.

Observational
Observational Model: Other
Time Perspective: Other
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Retention:   Samples With DNA
Description:
DNA isolated from peripheral blood.
Non-Probability Sample
Patients who come to Hadassah Hospital for anemia with microcytosis who are found to have alpha thalassemia.
Alpha Thalassemia
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Rund D, Filon D, Jackson N, Asher N, Oron-Karni V, Sacha T, Czekalska S, Oppenheim A. An unexpectedly high frequency of heterozygosity for alpha-thalassemia in Ashkenazi Jews. Blood Cells Mol Dis. 2004 Jul-Aug;33(1):1-3.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
100
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July 1, 2017
July 1, 2017   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • diagnosis of deletional alpha thalassemia

Exclusion Criteria:

  • under age 18
Sexes Eligible for Study: All
18 Years and older   (Adult, Older Adult)
No
Contact information is only displayed when the study is recruiting subjects
Israel
 
 
NCT00159029
152910-HMO-CTIL
No
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Deborah Rund, Hadassah Medical Organization
Deborah Rund
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Principal Investigator: Deborah Rund, MD Hadassah Medical Organization
Hadassah Medical Organization
August 2017