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Genetic Predictors of Outcome in HCM Patients

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ClinicalTrials.gov Identifier: NCT00156429
Recruitment Status : Active, not recruiting
First Posted : September 12, 2005
Last Update Posted : January 4, 2018
Sponsor:
Information provided by (Responsible Party):
Timothy Wong, University of Pittsburgh

September 8, 2005
September 12, 2005
January 4, 2018
July 2005
May 2020   (Final data collection date for primary outcome measure)
Genetic testing [ Time Frame: Day 1 at the time of enrollment ]
AR polymorphisms will be correlated to progression of LVH and clinical outcome in patients with HCM.
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Complete list of historical versions of study NCT00156429 on ClinicalTrials.gov Archive Site
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Genetic Predictors of Outcome in HCM Patients
Genetic Predictors of Outcome in HCM Patients
This is a retrospective review of the data available on patients and their family members with HCM and prospective follow-up of this cohort for clinical outcome and diagnostic studies. Genetic samples are being examined in this cohort to determine whether certain to determine whether certain beta-AR polymorphisms as well as other common genetic polymorphisms are associated with different morphological features, such as LVH in patients with HCM and whether these polymorphisms influence the clinical course and outcome in patients with HCM. For that purpose, we will build a database with clinical information including serial echocardiographic measurements for patients with HCM that have regular follow up and test them for beta-AR polymorphisms as well as other common genetic polymorphisms and other known cardiac-related polymorphisms that can potentially contribute to the morphologic differences seen in patients with HCM.
This is a retrospective review of the data available on patients and their family members with HCM and prospective follow-up of this cohort for clinical outcome and diagnostic studies. Genetic samples are being examined in this cohort to determine whether certain to determine whether certain beta-AR polymorphisms as well as other common genetic polymorphisms are associated with different morphological features, such as LVH in patients with HCM and whether these polymorphisms influence the clinical course and outcome in patients with HCM. For that purpose, we will build a database with clinical information including serial echocardiographic measurements for patients with HCM that have regular follow up and test them for beta-AR polymorphisms as well as other common genetic polymorphisms and other known cardiac-related polymorphisms that can potentially contribute to the morphologic differences seen in patients with HCM.
Observational
Observational Model: Cohort
Time Perspective: Prospective
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Retention:   Samples With DNA
Description:
Blood sample for DNA analysis
Non-Probability Sample
patients with HCM
Hypertrophic Cardiomyopathy
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
540
200
May 2020
May 2020   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • 18+ years of age
  • Diagnosed with HCM defined by the presence of left ventricular hypertrophy with minimal wall thickness >/= 15mm without the presence of hypertension or systemic disease that can account for the degree of hypertrophy.

Exclusion Criteria:

  • Hypertension present prior to the diagnosis of HCM
  • aortic stenosis with aortic valve area < 1cm2
  • known systemic disease that can cause LVH, such as infiltrative diseases
  • able and willing to provide informed consent
Sexes Eligible for Study: All
18 Years and older   (Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
United States
 
 
NCT00156429
0507025
0507025
No
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Timothy Wong, University of Pittsburgh
University of Pittsburgh
Not Provided
Principal Investigator: Samir F. Saba, MD University of Pittsburgh
University of Pittsburgh
January 2018