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Comparison of Three Different Strategies to Prevent Propofol Induced Pain During Infusion

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ClinicalTrials.gov Identifier: NCT00146926
Recruitment Status : Unknown
Verified April 2007 by Hospices Civils de Lyon.
Recruitment status was:  Active, not recruiting
First Posted : September 7, 2005
Last Update Posted : April 27, 2007
Information provided by:
Hospices Civils de Lyon

September 5, 2005
September 7, 2005
April 27, 2007
September 2005
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After prophylactic solution, evaluation of the pain caused by injection of propofol with a four-point scale before lose of consciousness
Same as current
Complete list of historical versions of study NCT00146926 on ClinicalTrials.gov Archive Site
  • Explicite and implicite memory of pain immediately after surgery and on day one
  • Adverse effects
Same as current
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Comparison of Three Different Strategies to Prevent Propofol Induced Pain During Infusion
Comparison of Three Different Strategies to Prevent Propofol Induced Pain During Infusion
Propofol is a popular intravenous drug to induce anesthesia but it causes local pain with an incidence between 40 and 90%. Three different strategies to prevent propofol induced pain will be studied compared with placebo. Pain will be scored with a four-point scale.
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Phase 3
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Induction of Total Intravenous General Anesthesia
  • Drug: kétamine 20mg
  • Drug: ephedrine 3mg
  • Drug: lidocaine 40mg
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
Unknown status
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Inclusion Criteria:

Healthy adults (ASA 1-2) for scheduled surgery under general anesthesia with propofol

Exclusion Criteria:

  • pregnant
  • sedative or analgesic drug 24h before surgery
  • allergy with drug used in the study
  • difficulty of communication
  • absence of informed written consent
Sexes Eligible for Study: All
18 Years to 75 Years   (Adult, Senior)
Contact information is only displayed when the study is recruiting subjects
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Hospices Civils de Lyon
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Principal Investigator: Vincent PIRIOU, MD Hospices Civils de Lyon
Hospices Civils de Lyon
April 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP