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Psychodynamic Therapy For Co-occurring Borderline Personality Disorder and Alcohol Use Disorder

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
State University of New York - Upstate Medical University
ClinicalTrials.gov Identifier:
NCT00145678
First received: September 1, 2005
Last updated: January 5, 2015
Last verified: January 2015

September 1, 2005
January 5, 2015
June 2004
May 2010   (final data collection date for primary outcome measure)
episodes of parasuicide, alcohol intoxication, institutional care [ Time Frame: 12 months ] [ Designated as safety issue: Yes ]
episodes of self-injury, self-reported alcohol use, inpatient psychiatry days
Complete list of historical versions of study NCT00145678 on ClinicalTrials.gov Archive Site
depression, dissociation, core symptoms of borderline pd, perceived social support [ Time Frame: 12 months ] [ Designated as safety issue: No ]
depression, dissociation, social and occupational functioning
Not Provided
Not Provided
 
Psychodynamic Therapy For Co-occurring Borderline Personality Disorder and Alcohol Use Disorder
Psychodynamic Therapy for Patients With Borderline Personality Disorder and Alcohol Abuse
The purpose of the study is to determine the feasibility and effectiveness of a modified form of psychodynamic psychotherapy for persons suffering from co-occurring borderline personality disorder and an alcohol use disorder.

Borderline Personality Disorder (BPD) is a condition that can cause significant distress and increased risk of death. Many persons with BPD also have an alcohol use disorder (AUD) and there is evidence that this can worsen the outcome and course of both disorders.

A manual-based form of psychodynamic therapy (PT), labeled dynamic deconstructive psychotherapy, has been developed for particularly challenging patients with BPD, especially those with co-occurring substance use disorders. It aims to remediate specific neurocognitive capacities that are responsible for processing of emotional experiences, and so diminishes symptoms of BPD and promotes the development of a coherent and differentiated self-structure. PT has been shown to be helpful for BPD, but has not been tested for people who have BPD with co-occurring substance use disorders.

The proposed study is a randomized controlled trial of PT for persons with BPD and co-occurring AUD that will generate some initial data that can be used to determine the need and feasibility for further outcome studies. Participants are randomized to either a study group receiving weekly PT or to a control group receiving usual care. Enrollment is 15 participants in each group. The study group will receive 12-18 months of PT, with naturalistic follow-up. Outcome measures are administered by a research assistant at enrollment, 3 months, 6 months, 9 months, 12 months, and 30 months.

The investigators anticipate that the PT group will show trends towards better retention in treatment and greater reduction in parasuicides, alcohol misuse, and institutional care. If so, this would have important and positive implications for the large group of patients who suffer from BPD and co-occurring AUD.

Interventional
Phase 2
Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment
  • Borderline Personality Disorder
  • Alcohol Use Disorder
  • Behavioral: Psychodynamic Therapy
    Dynamic deconstructive psychotherapy is a time-limited (12-18 month) manual-based form of psychodynamic therapy that aims to remediate specific neurocognitive capacities responsible for processing of emotional experiences.
    Other Name: Dynamic Deconstructive Psychotherapy
  • Behavioral: Optimized Community Care
    individual and group psychotherapy in a private practice, clinic, and/or rehab setting, with an eclectic orientation
    Other Name: Treatment as Usual
  • Experimental: dynamic deconstructive psychotherapy
    weekly individual psychotherapy of 50 minute duration lasting 12-18 months
    Intervention: Behavioral: Psychodynamic Therapy
  • Active Comparator: optimized community care
    eclectic weekly individual and group psychotherapy, as well as drug and alcohol rehabilitation
    Intervention: Behavioral: Optimized Community Care

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
30
May 2010
May 2010   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Age between 18 and 45 years
  • Meets diagnostic criteria for borderline personality disorder and for active alcohol abuse or dependence
  • At least average intelligence

Exclusion Criteria:

  • Meets diagnostic criteria for schizophrenia, or schizoaffective disorder
Both
18 Years to 45 Years   (Adult)
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00145678
SUNY UMU IRB 4968, 130230-44
No
Not Provided
Not Provided
State University of New York - Upstate Medical University
State University of New York - Upstate Medical University
Not Provided
Principal Investigator: Robert J. Gregory, M.D. State University of New York - Upstate Medical University
State University of New York - Upstate Medical University
January 2015

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP