Implementation of a New Strategy to Identify HNPCC Patients

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00141466
Recruitment Status : Unknown
Verified February 2007 by Radboud University.
Recruitment status was:  Recruiting
First Posted : September 1, 2005
Last Update Posted : April 23, 2008
ZonMw: The Netherlands Organisation for Health Research and Development
Information provided by:
Radboud University

August 31, 2005
September 1, 2005
April 23, 2008
September 2005
Not Provided
  • Efficacy of inclusion of eligible CRC-patients for MSI testing by pathologists.
  • Efficacy of referral of patients who are MSI positive to a clinical geneticist by surgeons.
Same as current
Complete list of historical versions of study NCT00141466 on Archive Site
  • Experiences with and acceptance of changed physician practice roles by patients and clinicians.
  • Cost efficacy of the implementation procedures.
Same as current
Not Provided
Not Provided
Implementation of a New Strategy to Identify HNPCC Patients
Cost Effectiveness of Two Different Implementation Procedures to Change Clinicians Practice Roles in the Detection of Hereditary Colorectal Cancer
The purpose of this study is to compare two different strategies to implement a new method to identify patients with HNPCC, which appeared cost-effective and feasible. The effectiveness, costs and feasibility of both of the implementation strategies will be assessed.
The Radboud University Nijmegen Medical Centre developed a new method to identify patients with HNPCC. This method appeared cost-effective and feasible. Using this new method 70% of the HNPCC patients will be identified as compared to less than 30% when the current method is used. However, this new method does not implement itself; large gaps exists between best evidence and daily practice. This study will compare an intensive strategy, consisting of distribution of educational materials, education, feedback and reminders, with a minimal strategy, only consisting of distribution of a critical care pathway. The aim is to find the most cost-effective strategy to implement the new method to identify patients with HNPCC in the Netherlands.
Not Applicable
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single
  • Colorectal Neoplasms
  • Hereditary Nonpolyposis Colorectal Cancer
  • Behavioral: Education for professionals
  • Behavioral: Distribution of educational materials
  • Behavioral: Feedback for professionals
  • Behavioral: Reminders for professionals
Not Provided

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
Unknown status
Same as current
July 2007
Not Provided

Inclusion Criteria:

  • Colorectal cancer before the age of 50 years
  • Second colorectal cancer at any age
  • Colorectal cancer and other HNPCC associated extracolonic cancer irrespective of age at diagnosis
  • Adenoma with high grade dysplasia diagnosed before the age of 40 years
Sexes Eligible for Study: All
Child, Adult, Older Adult
Contact information is only displayed when the study is recruiting subjects
ZonMw nr. 945-14-107
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Radboud University
ZonMw: The Netherlands Organisation for Health Research and Development
Principal Investigator: Nicoline Hoogerbrugge, MD PhD Department of Human Genetics, Radboud University Nijmegen Medical Center
Principal Investigator: Rosella P Hermens, MSc PhD Center of Quality of Care Research, Radboud University Nijmegen Medical Center
Radboud University
February 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP