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Dopaminergic Enhancement of Learning and Memory in Healthy Adults and Patients With Dyslexia

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified September 2006 by University Hospital Muenster.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00111371
First Posted: May 20, 2005
Last Update Posted: December 5, 2014
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
University Hospital Muenster
May 19, 2005
May 20, 2005
December 5, 2014
January 2005
Not Provided
  • Boost in training success (percent correct) through levodopa as compared to placebo
  • Boost in training success (reaction times) through levodopa as compared to placebo
  • Increased performance on reading, spelling and writing tests in dyslexic patients treated with levodopa as compared to placebo
Same as current
Complete list of historical versions of study NCT00111371 on ClinicalTrials.gov Archive Site
Stability of improvements one month post training
Same as current
Not Provided
Not Provided
 
Dopaminergic Enhancement of Learning and Memory in Healthy Adults and Patients With Dyslexia
Dopaminergic Enhancement of Learning and Memory (LL_001, Project on Dyslexia)
This study aims to determine whether levodopa, in combination with a high frequency training of (grammatical) rules, is effective in boosting learning success in healthy subjects and whether this kind of training in combination with levodopa improves reading and spelling abilities of patients with dyslexia.
Prior work by our group shows that d-amphetamine and the dopamine precursor levodopa markedly improve word learning success in healthy subjects. In this randomized, placebo-controlled, double-blind trial, we probe whether daily administration of levodopa, coupled with a training of grammatical rules, improves the training success in healthy adults as compared to placebo administration. In the second step of this study, patients with dyslexia will be trained with the identical protocol. We postulate that the combination of intensive training in language rules and levodopa improves the reading, writing, and spelling abilities of patients with dyslexia.
Interventional
Phase 4
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment
Dyslexia
Drug: Levodopa
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Unknown status
100
October 2015
Not Provided

Inclusion Criteria:

  • Right-handedness
  • Age between 18-35 years
  • Primary language: German

Exclusion Criteria:

  • Known allergy to levodopa or tetrazine
  • History of medication/drug abuse
  • Acute nicotine withdrawal or > 10 cigarettes per day
  • >6 cups/glasses of coffee, caffeine drinks or energy drinks per day
  • >50 grams of alcohol per day
  • Hypertonia
  • Arteriosclerosis
  • Diabetes, asthma, or glaucoma
  • Psychiatric disease
  • Neurologic disease
  • Other medication
Sexes Eligible for Study: Male
18 Years to 35 Years   (Adult)
Yes
Contact information is only displayed when the study is recruiting subjects
Germany
 
 
NCT00111371
LL-001; Project on Dyslexia
Not Provided
Not Provided
Not Provided
Not Provided
University Hospital Muenster
Not Provided
Principal Investigator: Stefan Knecht, Prof. Dr. Dept. of Neurology, Universityclinic of Muenster
University Hospital Muenster
September 2006

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP