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Brain Reaction to Treatment of Nicotine Dependence

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00108173
First Posted: April 15, 2005
Last Update Posted: April 9, 2013
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
VA Office of Research and Development
April 14, 2005
April 15, 2005
April 9, 2013
October 2002
April 2007   (Final data collection date for primary outcome measure)
2-FA PET scan results [ Time Frame: Within the first few weeks of study initiation ]
Brain activity and activation in response to cigarette-related cues
Not Provided
Complete list of historical versions of study NCT00108173 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Brain Reaction to Treatment of Nicotine Dependence
Neural Substrates of Treatment for Nicotine Dependence

The purpose of the study was to determine how the treatments for cigarette craving work.

Hypothesis: During exposure to cigarette-related cues, heavy smokers will have greater reductions in regional brain activation from before to after both forms of active treatments than from before to after placebo.

PET and fMRI scanning were used to examine brain activity and activation in cigarette smokers in response to cigarette-related cues.
Interventional
Phase 1
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Nicotine Dependence
Drug: Zyban
Arm 1
Intervention: Drug: Zyban
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
104
June 2011
April 2007   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Heavy smoker, more than one pack per day
  • Free of medical conditions or medications that affect brain activity
  • Not pregnant

Exclusion Criteria:

Drug or alcohol dependence Mental Illness Pregnancy Medications that affect brain function Unstable medical conditions

Sexes Eligible for Study: All
21 Years to 60 Years   (Adult)
No
Contact information is only displayed when the study is recruiting subjects
United States
 
 
NCT00108173
ADRD-018-02S
No
Not Provided
Not Provided
VA Office of Research and Development
VA Office of Research and Development
Not Provided
Principal Investigator: Arthur L. Brody, MD VA Greater Los Angeles Healthcare System, West LA
VA Office of Research and Development
April 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP