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Childhood Autism Risks From Genetics and the Environment (The CHARGE Study)

This study is ongoing, but not recruiting participants.
Sponsor:
Collaborators:
University of California, Davis
University of California, Los Angeles
Information provided by:
National Institute of Environmental Health Sciences (NIEHS)
ClinicalTrials.gov Identifier:
NCT00106652
First received: March 28, 2005
Last updated: April 13, 2015
Last verified: April 2015

March 28, 2005
April 13, 2015
September 2001
May 2018   (final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT00106652 on ClinicalTrials.gov Archive Site
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Childhood Autism Risks From Genetics and the Environment (The CHARGE Study)
Environmental Factors in the Etiology of Autism
The purpose of this study is to understand how genes, environment, and the interplay between the two, influences the development of autism and other neurodevelopmental disorders.

The causes and contributing factors for autism are poorly understood. Evidence suggests that incidence is increasing, but diagnostic changes and improvements may be playing a role. Both genetic and environmental factors appear to play a role. Autopsy studies demonstrate structural changes in the brain and clinical investigations reveal neurophysiologic differences in information processing in autistic versus normal children. Members of our team recently demonstrated altered levels of certain neuropeptides at birth in children who later developed autism.

This case-control study is the first large-scale epidemiologic investigation of underlying causes for autism and triggers of regression. This study capitalizes on the strengths of the case-control design, which is well suited to examine a broad array of factors for rare conditions that are thought to be multifactorial. Comparisons will be made with both general population controls and mentally retarded children.

The aims are to assess the influence of exogenous exposures, the role of susceptibility factors, and the interplay between these two in the etiology of autism and its phenotypic variation. Chemicals with known or suspected neurodevelopmental toxicity, such as PCB's, certain pesticides, and metals, are being investigated. This study pursues several hypotheses that have recently gained attention, including the combined measles, mumps, rubella vaccine and mercury present in vaccines given during infancy and early childhood. Additionally, biochemical susceptibility is examined through characterization of metabolic, immunologic, and neuronal gene expression profiles and genetic polymorphisms.

Observational
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  • Autism
  • Developmental Disabilities
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
2000
May 2018
May 2018   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Children between 2 and 5 years old
  • Born in California
  • Parents must speak either English or Spanish
  • Children must be living with at least one biologic parent

Exclusion Criteria:

  • Children not meeting eligibility criteria listed above
  • Children not residing in selected geographical areas (please contact for more information about specific study locations)
Both
24 Months to 60 Months   (Child)
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00106652
11269-CP-001, 200210574-4
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National Institute of Environmental Health Sciences (NIEHS)
  • University of California, Davis
  • University of California, Los Angeles
Principal Investigator: Isaac N. Pessah, Ph.D. University of California, Davis
Study Director: Irva Hertz-Picciotto, Ph.D. University of California, Davis
National Institute of Environmental Health Sciences (NIEHS)
April 2015

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP