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Interactions Between Cranberry Juice and Antibiotics Used to Treat Urinary Tract Infections

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00084201
First Posted: June 9, 2004
Last Update Posted: November 30, 2006
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
National Center for Complementary and Integrative Health (NCCIH)
June 8, 2004
June 9, 2004
November 30, 2006
July 2006
Not Provided
Drug Elmination
Not Provided
Complete list of historical versions of study NCT00084201 on ClinicalTrials.gov Archive Site
Drug absorption
Not Provided
Not Provided
Not Provided
 
Interactions Between Cranberry Juice and Antibiotics Used to Treat Urinary Tract Infections
Cranberry: Interactions With Anti-Infectious Agents
The purpose of study is to determine whether cranberry juice interacts with antibiotics used to treat urinary tract infections (UTIs).

Although evidence of its effectiveness is limited, cranberry juice is widely used to prevent urinary tract infections (UTIs). However, recent studies have shown that cranberry juice may affect the way the body absorbs and metabolizes antibiotics used to treat UTIs. This study will determine whether concurrent cranberry juice administration lowers the urinary concentrations of two commonly used antibiotics, amoxicillin and cefaclor.

This study will involve children being treated for UTIs and adults without UTIs. All of the children will continue their prescribed amoxicillin/cefaclor treatment. After 7 to 10 days of antibiotic treatment, the children will be assigned to receive either cranberry juice for 2 days or no additional treatment. Urine samples will be collected from all child participants before and after the administration of cranberry juice to examine the excretion of the antibiotics.

Adult participants will receive two different doses of amoxicillin, with or without cranberry juice. Blood and urine samples will be collected to evaluate the effect of cranberry juice on the absorption and elimination of amoxicillin.

Interventional
Not Provided
Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Urinary Tract Infections
  • Drug: Cranberry juice
  • Drug: Amoxicillin
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
18
June 2007
Not Provided

Inclusion Criteria for Children:

  • Urinary tract infection (UTI) treated with cefaclor or amoxicillin

Inclusion Criteria for Adults:

  • No UTI

Exclusion Criteria:

  • Allergies to antibiotics
  • Use of medications other than oral contraceptives
  • Pregnancy or breast-feeding
  • Smoker
Sexes Eligible for Study: All
6 Years to 50 Years   (Child, Adult)
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
 
NCT00084201
R21AT002077-01( U.S. NIH Grant/Contract )
Not Provided
Not Provided
Not Provided
Not Provided
National Center for Complementary and Integrative Health (NCCIH)
Not Provided
Principal Investigator: Gail D Anderson, PhD University of Washington
National Center for Complementary and Integrative Health (NCCIH)
November 2006

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP