Brain Activity in Visual-Motor Behavior
|First Submitted Date||February 9, 2004|
|First Posted Date||February 10, 2004|
|Last Update Posted Date||July 2, 2017|
|Start Date||February 6, 2004|
|Primary Completion Date||Not Provided|
|Current Primary Outcome Measures||Not Provided|
|Original Primary Outcome Measures||Not Provided|
|Change History||Complete list of historical versions of study NCT00077038 on ClinicalTrials.gov Archive Site|
|Current Secondary Outcome Measures||Not Provided|
|Original Secondary Outcome Measures||Not Provided|
|Current Other Outcome Measures||Not Provided|
|Original Other Outcome Measures||Not Provided|
|Brief Title||Brain Activity in Visual-Motor Behavior|
|Official Title||Modulation of the Visual Information Processing in the Human Parieto-Frontal Network as Studied by a Frequency Tagging Technique During Visuomotor Tracking|
This study will examine how the brain works when people look at an object, follow a moving object with their eyes, and reach out their hand to an object. Different areas of the brain work together in reaching out a hand to an object. These areas are also important for concentrating on objects or following them with the eyes. This study will use magnetoencephalography (MEG) to observe more precisely how discrete parts of the brain work during these movements. MEG is a new technique for recording magnetic field changes produced by brain activity.
Healthy normal volunteers 20 years of age and older who are right-handed and who have no history of brain or eye disease may be eligible for this study. Candidates will be screened with a medical history and brief physical examination. They will complete questionnaires for MEG screening and for determining handedness.
Participants undergo MEG recording and magnetic resonance imaging (MRI). For MEG, the subject sits comfortably in front of a computer screen, and a cone containing magnetic field detectors is lowered onto the head. Electrodes are placed on both sides of the outer part of the eyelids and just above and below the left eye to monitor eye movement. During MEG, subjects perform the following tasks:
Subjects practice each task before MEG recording starts. Then they perform each task twice in random order, with a 1- or 2-minute break between tasks.
Subjects who do not have previous MRI images filed in NINDS's database undergo MRI scanning. MRI uses a strong magnetic field and radio waves to obtain images of body organs and tissues. The scanner is a metal cylinder surrounded by a strong magnetic field. Subjects lie still on a table that can slide in an out of the cylinder. They can communicate with the MRI staff at all times during the procedure.
The hypothesis of this study is that the parieto-frontal network is activated by visuomotor behavior in humans.
To detect frontal and parietal cortical activity during a visuomotor task with frequency modulated visual stimuli using magnetoencephalography (MEG).
To reveal how the parieto-frontal activities change according to different conditions of attention, gaze, and motor output.
Right handed normal volunteers with no known history of neurological or ophthalmological diseases will be recruited to participate in this study.
This study is a combination of a frequency tagging method and an MEG. Visual stimuli are presented, flickering in specific (tagged) frequencies. The cortical distribution of the visual information is estimated from the tagged frequency response of the MEG signal. We will use a visuomotor tracking task with a multifactorial task design (attention, target motion, position in retinal coordinate, and manual tracking) to evaluate the effect of each factor separately.
We will use the adaptive linear-filter technique known as synthetic aperture magnetometry (SAM) to estimate the source location and strength of the tagged frequencies. The estimated cortical source activity power at the frontal and parietal cortices will be group analyzed with multiple logistic models and by analysis of variance (ANOVA) with correction for multiple comparisons.
|Study Design||Not Provided|
|Target Follow-Up Duration||Not Provided|
|Sampling Method||Not Provided|
|Study Population||Not Provided|
|Study Groups/Cohorts||Not Provided|
|Publications *||Glover S. Optic ataxia as a deficit specific to the on-line control of actions. Neurosci Biobehav Rev. 2003 Aug;27(5):447-56. Review.|
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
|Estimated Completion Date||March 31, 2007|
|Primary Completion Date||Not Provided|
The subjects must be 20 years old or older and right-handed as screened by Edinburgh handedness inventory.
They must be healthy and have no known history of neurological or ophthalmological diseases.
Subjects under the age of 20 will be excluded from this study.
Subjects who match the criteria below will be excluded from this study due to human subject protection and because they may negatively affect the MEG data quality.
Subjects wearing glasses.
Subjects with involuntary movement or dyskinesia.
Subjects with spontaneous nystagmus.
Subjects who can not execute the eye or manual tracking after sufficient practice time.
Subjects with metal objects in the body.
Subjects with history of severe head trauma.
|Ages||20 Years and older (Adult, Senior)|
|Accepts Healthy Volunteers||Yes|
|Contacts||Contact information is only displayed when the study is recruiting subjects|
|Listed Location Countries||United States|
|Removed Location Countries|
|Other Study ID Numbers||040117
|Has Data Monitoring Committee||Not Provided|
|U.S. FDA-regulated Product||Not Provided|
|IPD Sharing Statement||Not Provided|
|Responsible Party||Not Provided|
|Study Sponsor||National Institute of Neurological Disorders and Stroke (NINDS)|
|PRS Account||National Institutes of Health Clinical Center (CC)|
|Verification Date||March 31, 2007|