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Lupus Genetics Studies (LFRR)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00071175
First Posted: October 15, 2003
Last Update Posted: September 18, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborators:
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by (Responsible Party):
Oklahoma Medical Research Foundation
October 14, 2003
October 15, 2003
September 18, 2017
October 1995
September 2012   (Final data collection date for primary outcome measure)
Not Provided
Not Provided
Complete list of historical versions of study NCT00071175 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Lupus Genetics Studies
Lupus Genetic Studies; Lupus Family Registry & Repository
The Lupus Genetics Studies and Lupus Family Registry & Repository are working to find the genes that reveal the causes of systemic lupus erythematosus (SLE, or lupus). The study is enrolling families of all ethnic backgrounds from the United States, Canada, Puerto Rico, and the Virgin Islands that have one or more living members diagnosed with SLE.

SLE is an often crippling and potentially fatal autoimmune disease that is nine times more prevalent in women than in men, and four times more likely to affect African American females than Caucasian females. It is suspected that a genetic predisposition along with environmental factors contribute to the clinical manifestation of SLE. The Lupus Genetics Studies consist of several familial SLE studies, including the Lupus Family Registry & Repository (LFRR, formerly known as the Lupus Multiplex Registry & Repository, or LMRR). The Lupus Studies enroll families of all ethnicities with one or more members diagnosed with systemic lupus to determine what genes contribute to the development of the disease.

Additionally, the Lupus Family Registry & Repository is the largest repository of its kind in North America. In addition to the research done on site, the Repository serves as a national resource for scientists interested in conducting research on SLE and families either simplex or multiplex for lupus. Data, serum samples, and DNA samples are available to researchers. By collecting families in which two or more living individuals have been diagnosed with SLE, the study is utilizing the genetic link between the affected family members to discover disease-associated genes.

Records will be requested from the patients' treating physicians to document various lupus symptoms and related problems. One-time blood samples will be collected from the patients as well as from certain family members and an unrelated volunteer. There is no cost to participate and the study pays for sample draws and shipping.

Observational
Observational Model: Family-Based
Time Perspective: Retrospective
Not Provided
Retention:   Samples With DNA
Description:
DNA, sera, plasma, cell lines
Non-Probability Sample
Patients diagnosed with SLE Families with living members diagnosed with SLE
Systemic Lupus Erythematosus
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
3460
November 2013
September 2012   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Families in which one or more living members have been diagnosed with systemic lupus erythematosus
Sexes Eligible for Study: All
Child, Adult, Senior
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
 
NCT00071175
NIAMS-103
5P01AR049084-09 ( U.S. NIH Grant/Contract )
AI24717
AR42460
AR049084
AR52253
AR62277
No
Not Provided
Not Provided
Oklahoma Medical Research Foundation
Oklahoma Medical Research Foundation
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
  • National Heart, Lung, and Blood Institute (NHLBI)
Principal Investigator: John B. Harley, MD, PhD Member & Program Head, Arthritis and Immunology Research Program; Oklahoma Medical Research Foundation
Oklahoma Medical Research Foundation
September 2017