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Genetic Registry for Rheumatoid Arthritis (NARAC)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00069472
First Posted: September 29, 2003
Last Update Posted: September 10, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborators:
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Arthritis Foundation
Information provided by (Responsible Party):
Peter Gregersen, North Shore Long Island Jewish Health System
September 25, 2003
September 29, 2003
September 10, 2015
October 2002
August 2015   (Final data collection date for primary outcome measure)
Genetic Association with risk for rheumatoid arthritis [ Time Frame: 10 years ]
The project aims to identify risk alleles for rheumatoid arthritis using association methods in trio families, combined with data from singleton cases and multiplex families
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Complete list of historical versions of study NCT00069472 on ClinicalTrials.gov Archive Site
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Genetic Registry for Rheumatoid Arthritis
Genetics of Rheumatoid Arthritis Registry
Many genes are thought to contribute to rheumatoid arthritis (RA). This study will attempt to identify genes that may contribute to RA.

The identification of genes for complex disorders such as RA requires large numbers of genetically informative families. This study enrolls people diagnosed with with RA and their families.

This study will enroll 1000 RA patients and their parents. Participants with RA will be evaluated at his or her doctor's office or other location convenient for the participant. Participants will have a brief phone interview with a study coordinator and a blood sample will be obtained. Disease evaluation will be done at one visit and will include confirmation of diagnosis, a 28 joint count, joint alignment and mobility score (JAMS) and administration of a health assessment questionnaire.

Observational
Observational Model: Family-Based
Time Perspective: Cross-Sectional
Not Provided
Retention:   Samples With DNA
Description:
DNA, plasma, serum and cells
Non-Probability Sample
Persons with RA who have two living biological parents. Parents can be affected or unaffected with RA. We call the family units "trios".
Rheumatoid Arthritis
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
1062
August 2015
August 2015   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Adult onset RA
  • Diagnosis of RA made between 18 and 60 years old
  • Both parents alive and willing to participate
  • Parents may have diagnosis of RA (affected) or be unaffected

Exclusion Criteria:

  • Inflammatory bowel disease
  • Lupus
  • Psoriatic arthritis
Sexes Eligible for Study: All
18 Years and older   (Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
United States
 
 
NCT00069472
NIAMS-107
N01AR72232-001 ( U.S. NIH Grant/Contract )
No
Not Provided
Not Provided
Peter Gregersen, North Shore Long Island Jewish Health System
Northwell Health
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
  • Arthritis Foundation
Principal Investigator: Peter K. Gregersen, MD North Shore University Hospital
Northwell Health
September 2015