Try our beta test site

Treatment Plan to Decrease Drug Exposure in HIV Infected Adolescents

This study has been withdrawn prior to enrollment.
(The study was never opened for enrollment; concept became irrelevant as other study results became available.)
National Institute on Drug Abuse (NIDA)
National Institute of Mental Health (NIMH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Information provided by (Responsible Party):
Westat Identifier:
First received: August 25, 2003
Last updated: July 13, 2016
Last verified: July 2016

August 25, 2003
July 13, 2016
July 2003
Not Provided
Not Provided
Not Provided
Complete list of historical versions of study NCT00067574 on Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
Treatment Plan to Decrease Drug Exposure in HIV Infected Adolescents
Structured Treatment Interruption as an Autovaccination Approach to Enhance Immune Based HIV-1 Control in an Adolescent/Young Adult Population
This study will attempt to stimulate the immune system in HIV infected adolescents and young adults so that it can better control the HIV infection. When anti-HIV drugs are stopped for a period of time, the virus "grows back." This may stimulate the immune system, which may then be more effective in controlling the virus.

The focus of this study is to use Structured Treatment Interruption (STI) as an approach to auto-immunization. The STI management schema is based on current understanding of HIV-1 viral dynamics, pharmacology of available antiretroviral medications, and HIV-specific host responses. This is a Phase II trial to provide preliminary data on the feasibility and possible efficacy of using STI to enhance immune-based control of HIV-1 replication. A steady state HIV-1 viral load determined from historical tests prior to initiating highly active antiretroviral therapy (HAART) will be compared to the steady state viral load post-STI. HIV-1 specific CD4 and CD8 cell responses will be measured before and after the period of STI management and HIV-1 specific CD8 cell maturational phenotype will be assessed and correlated with ability to control viral replication.

Adolescents and young adults who have either had sustained viral suppression on HAART for at least 2 years or who have had sustained viral suppression from 3 to 6 months will be eligible for this study. Participants will have 12 weeks of HAART followed by 2 to 4 weeks of treatment interruption. Participants will undergo three rounds of this regimen. After the third STI, participants will have an additional 12 weeks of HAART and then stop therapy. Participants will be monitored off HAART for up to 20 weeks. During this time, if there is evidence of HIV progression (two consecutive viral loads exceeding 10,000 copies/ml; two consecutive CD4 cell counts under 350 cells/microL; two consecutive CD4 percentages less than 15%; or two consecutive CD4 cell counts less than 50% of baseline), standard continuous antiretroviral therapy will be reinstituted. Plasma HIV RNA will be tested monthly during therapy and weekly while subjects are off treatment. Immunologic studies are monthly throughout the study. Participants will be involved in the study for approximately 2 years.

Phase 2
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
HIV Infections
Behavioral: Structured treatment interruption
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
Not Provided
Not Provided

Inclusion Criteria

  • Acquired HIV infection after age 12 years
  • CD4 cell count greater than 500 cells/microL within 30 days of study entry
  • Either on HAART for 3 to 6 months with HIV-1 RNA < 400 copies/ml or on HAART for more than 2 years with at least one HIV-1 RNA < 400 copies/ml each six month period
  • HAART regimen of two NRTIs and at least one PI (not nelfinavir)
  • HIV-1 RNA 5,000 copies/ml prior to HAART and documented CD4 cell values
  • CMV positive
  • Ability and willingness of subject (and parent/guardian where required) to give informed consent

Exclusion Criteria

  • Started initial HAART regimen less than one year after known HIV-1 seroconversion
  • Immunosuppressive therapy
  • Certain medications
  • Pregnancy
  • Evidence of an opportunistic infection
  • Laboratory values that are classified as Grade 3 or higher toxicities at the time of study enrollment
Sexes Eligible for Study: All
14 Years to 21 Years   (Child, Adult)
Contact information is only displayed when the study is recruiting subjects
United States
ATN 008
Not Provided
Not Provided
Not Provided
Not Provided
  • National Institute on Drug Abuse (NIDA)
  • National Institute of Mental Health (NIMH)
  • National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Study Chair: Craig M Wilson, MD University of Alabama at Birmingham
July 2016

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP