We updated the design of this site on December 18, 2017. Learn more.
ClinicalTrials.gov Menu

Epidemiology of Carotid IMT Progression in MESA - Ancillary Study

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00063440
Recruitment Status : Completed
First Posted : June 30, 2003
Last Update Posted : February 8, 2013
Information provided by (Responsible Party):

June 26, 2003
June 30, 2003
February 8, 2013
June 2003
May 2008   (Final data collection date for primary outcome measure)
Common carotid artery intima-media thickness [ Time Frame: randomly selected at 2 years or 4 years in 1/2 of the cohort ]
Not Provided
Complete list of historical versions of study NCT00063440 on ClinicalTrials.gov Archive Site
Common carotid artery diameter [ Time Frame: randomly selected at 2 or 4 years for each 1/2 of the cohort ]
Not Provided
Not Provided
Not Provided
Epidemiology of Carotid IMT Progression in MESA - Ancillary Study
Not Provided
To determine the factors associated with progression of sub-clinical atherosclerosis and to evaluate the associations between the progression of sub-clinical atherosclerosis and the development of clinically manifest atherosclerosis.


Cardiovascular disease remains the leading cause of death in the United States and one of the leading causes of morbidity. New technology recently has allowed the non-invasive investigation of the extent of atherosclerosis in different vascular beds. Unfortunately, the clinical implications and significance of this new technology have not yet been fully examined nor has the interrelationship between these various measurements of clinical and sub-clinical atherosclerosis. The study is ancillary to the Multi-Ethnic Study of Atherosclerosis (MESA), an NHLBI-supported epidemiological study of atherosclerosis in several ethnic groups.


A longitudinal assessment of the carotid intima media thickness (IMT) will be added to the scheduled follow-up visits in MESA subjects in order to study the relationship between carotid IMT and a measure of calcium burden in the coronary vessels. In addition, studies will be conducted on how these two non-invasive markers of atherosclerosis relate to cardiovascular disease risk factors and clinical events.The study will utilize the MESA cohort involving 6500 subjects who will have baseline and four follow-up examinations. coronary artery calcification (CAC) and IMT are being obtained at baseline, with CAC determinations also scheduled at follow-up. IMT determinations will be added in conjunction with the CAC studies in the second and third exams and detailed analyses will be carried out on these two measures of atherosclerotic burden that may reflect different biologic processes.

Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Not Provided
Non-Probability Sample
Participants of the Multi-Ethnic Study of Atherosclerosis, a cross-sectional NIH population cohort originating from 6 regions in the United States
  • Atherosclerosis
  • Cardiovascular Diseases
  • Heart Diseases
  • Carotid Artery Diseases
  • Coronary Arteriosclerosis
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
May 2008
May 2008   (Final data collection date for primary outcome measure)
Members of MESA study
Sexes Eligible for Study: All
45 Years to 84 Years   (Adult, Senior)
Contact information is only displayed when the study is recruiting subjects
Not Provided
5R01HL069003-05 ( U.S. NIH Grant/Contract )
Not Provided
Not Provided
Not Provided
Tufts Medical Center
Tufts Medical Center
National Heart, Lung, and Blood Institute (NHLBI)
Principal Investigator: Joseph F Polak, MD, MPH Tufts Medical Center
Tufts Medical Center
February 2013