Antibiotic Treatment for Infections of Short Term In-dwelling Vascular Catheters Due to Gram Positive Bacteria

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00037050
Recruitment Status : Completed
First Posted : May 15, 2002
Last Update Posted : September 14, 2009
Information provided by:

May 14, 2002
May 15, 2002
September 14, 2009
April 2002
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  • The empiric treatment of patients with complicated skin and skin structure infections (cSSSI) related to an indwelling catheter;
  • The empiric treatment of patients with gram-positive catheter-related bloodstream infections.
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Complete list of historical versions of study NCT00037050 on Archive Site
Clinical efficacy of linezolid compared to vancomycin/oxacillin/dicloxacillin.2.Incidence of late metastatic sequelae associated with S. aureus infections in patients treated with linezolid
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Antibiotic Treatment for Infections of Short Term In-dwelling Vascular Catheters Due to Gram Positive Bacteria
Linezolid vs. Vancomycin/Oxacillin/Dicloxacillin in the Treatment of Catheter-Related Gram-Positive Bloodstream Infections
This study will treat patients who have a short term central catheter that is thought to be infected with a specific bacteria (gram positive bacteria)
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Phase 3
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
  • Bacterial Infections
  • Gram-Positive Bacterial Infections
  • Bacteremia
  • Drug: Linezolid
    Other Name: Zyvox
  • Drug: Vancomycin
  • Drug: Oxacillin
  • Drug: Dicloxacillin
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*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
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July 2005
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Inclusion Criteria:

  • Patients with a central indwelling catheter with signs and symptoms of infection

Exclusion Criteria:

  • Patients with tunneled catheter which cannot be removed.
  • Patients with evidence of endovascular infection including endocarditis.
  • Patients with infection of permanent intravascular devices.
  • Patients who have received more than 1 day of another antibiotic before enrollment.
  • Patients with HIV and low CD4 count.
Sexes Eligible for Study: All
13 Years and older   (Child, Adult, Older Adult)
Contact information is only displayed when the study is recruiting subjects
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Argentina,   Australia,   Austria,   Belgium,   Brazil,   Chile,   Colombia,   Czech Republic,   France,   Germany,   Greece,   Guatemala,   Hungary,   India,   Ireland,   Italy,   Mexico,   Pakistan,   Panama,   Peru,   Philippines,   Poland,   Portugal,   Russian Federation,   Slovakia,   South Africa,   Spain,   Thailand,   Turkey,   United States,   Venezuela
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Director, Clinical Trial Disclosure Group, Pfizer, Inc.
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Study Director: Pfizer Call Center Pfizer
September 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP