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Trial record 1 of 1 for:    6340591 [PUBMED-IDS]
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Enhanced Tactile (Touch) Spatial Acuity in Upper Limb Amputees

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ClinicalTrials.gov Identifier: NCT00028210
Recruitment Status : Completed
First Posted : December 18, 2001
Last Update Posted : March 4, 2008
Sponsor:
Information provided by:
National Institutes of Health Clinical Center (CC)

Tracking Information
First Submitted Date December 17, 2001
First Posted Date December 18, 2001
Last Update Posted Date March 4, 2008
Study Start Date December 2001
Primary Completion Date Not Provided
Current Primary Outcome Measures Not Provided
Original Primary Outcome Measures Not Provided
Change History Complete list of historical versions of study NCT00028210 on ClinicalTrials.gov Archive Site
Current Secondary Outcome Measures Not Provided
Original Secondary Outcome Measures Not Provided
Current Other Pre-specified Outcome Measures Not Provided
Original Other Pre-specified Outcome Measures Not Provided
 
Descriptive Information
Brief Title Enhanced Tactile (Touch) Spatial Acuity in Upper Limb Amputees
Official Title Enhancement of Tactile Spatial Acuity in Upper Limb Amputees
Brief Summary

This study will examine whether tactile (touch) abilities at the lip are more acute in people with upper limb amputation compared with healthy normal volunteers. People with an amputated upper limb have an expanded brain representation of the lip that may correlate with heightened tactile spatial acuity.

Normal volunteers will be recruited for this study. Candidates will be screened with physical and neurological examinations. (Amputee volunteers will be studied at the amputee clinic at the University of Tubingen, Germany.)

Participants will sit comfortably in a chair, wearing a blindfold, during the following experiments:

  • Plastic domes with grooves are placed on parts of the lower lip on either side for a few seconds. The volunteer is then asked to identify the direction of the grooves relative to the long axis of the lip.
  • The participant's arm is placed in a cast and the index finger is immobilized. The same test done on the lip is repeated on the distal part of the index finger.

Each part of the test lasts about 20 minutes, and the entire experiment takes about 2 hours.

Detailed Description Upper limb amputation leads to expansion of the cortical representation of the lip into the adjacent deafferented hand representation. It is conceivable that this enlargement of the lip representation may translate into a behavioral gain. The purpose of this protocol is to test the hypothesis that upper limb amputation in humans results in higher tactile spatial acuity at the lip. This would represent the first demonstration of chronic deafferentation-induced behavioral gains within the somatosensory system.
Study Type Observational
Study Design Not Provided
Target Follow-Up Duration Not Provided
Biospecimen Not Provided
Sampling Method Not Provided
Study Population Not Provided
Condition Amputation
Intervention Not Provided
Study Groups/Cohorts Not Provided
Publications *

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruitment Information
Recruitment Status Completed
Enrollment
 (submitted: June¬†23,¬†2005)
60
Original Enrollment Same as current
Study Completion Date March 2004
Primary Completion Date Not Provided
Eligibility Criteria

INCLUSION CRITERIA:

Normal volunteers who are willing and able to stay relaxed and collaborative for a period of up to 2 hours.

Subjects with upper limb amputation more than one year before testing.

EXCLUSION CRITERIA:

Neurological or psychiatric disease

Excessive callus at the palm of the fingers

Subjects, who are unable to perform or understand the task

Sex/Gender
Sexes Eligible for Study: All
Ages Child, Adult, Older Adult
Accepts Healthy Volunteers Yes
Contacts Contact information is only displayed when the study is recruiting subjects
Listed Location Countries United States
Removed Location Countries  
 
Administrative Information
NCT Number NCT00028210
Other Study ID Numbers 020067
02-N-0067
Has Data Monitoring Committee Not Provided
U.S. FDA-regulated Product Not Provided
IPD Sharing Statement Not Provided
Responsible Party Not Provided
Study Sponsor National Institute of Neurological Disorders and Stroke (NINDS)
Collaborators Not Provided
Investigators Not Provided
PRS Account National Institutes of Health Clinical Center (CC)
Verification Date March 2004