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Regulation of Sterol Homeostasis

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00018720
First Posted: July 5, 2001
Last Update Posted: January 21, 2009
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
VA Office of Research and Development
July 3, 2001
July 5, 2001
January 21, 2009
April 1996
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Complete list of historical versions of study NCT00018720 on ClinicalTrials.gov Archive Site
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Regulation of Sterol Homeostasis
Regulation of Sterol Homeostasis

The purpose of this study is to determine how people with high triglycerides metabolize and absorb bile acids, compounds made in the body from cholesterol.

This project has two objectives: A) To define the mechanism of impaired bile acid absorption in hypertriglyceridemia (specifically we will determine if the active or passive component of absorption is abnormal) and B) to determine the contribution of an alternative pathway of bile acid synthesis which begins with 27-hydroxylation of cholesterol. Because 27-hydroxylase is present in endothelial cells as well as liver, this pathway may play a role in removal of cholesterol from incipient atherosclerotic plaque.

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Observational
Time Perspective: Prospective
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Hypertriglyceridemia
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
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December 2000
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Hypertriglyceridemia and normal controls with normal lipids
Sexes Eligible for Study: All
18 Years to 75 Years   (Adult, Senior)
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
 
NCT00018720
GAST-026-95F
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VA Office of Research and Development
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Investigator: Norman Javitt, M.D.
Investigator: Alan Hofmann, M.D.
Investigator: Loren Zech, M.D.
VA Office of Research and Development
December 2004