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Differences in Brain Processing of First and Second Languages (Korean and English)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT00016510
Recruitment Status : Completed
First Posted : May 14, 2001
Last Update Posted : March 4, 2008
Sponsor:
Information provided by:
National Institutes of Health Clinical Center (CC)

Tracking Information
First Submitted Date May 12, 2001
First Posted Date May 14, 2001
Last Update Posted Date March 4, 2008
Study Start Date May 2001
Primary Completion Date Not Provided
Current Primary Outcome Measures Not Provided
Original Primary Outcome Measures Not Provided
Change History
Current Secondary Outcome Measures Not Provided
Original Secondary Outcome Measures Not Provided
Current Other Pre-specified Outcome Measures Not Provided
Original Other Pre-specified Outcome Measures Not Provided
 
Descriptive Information
Brief Title Differences in Brain Processing of First and Second Languages (Korean and English)
Official Title Differences of Verbal Working Memory and Translation Systems Between First and Second Languages: a Functional MRI Study
Brief Summary

This study will examine differences in how the brain processes English and Korean in native Korean speakers who are fluent and non-fluent in English as a second language. It is thought that people who are non-fluent in a second language process the second language differently from their native language-using different areas of the brain and requiring additional working memory. The study will increase understanding of language acquisition, brain plasticity and bilingualism.

Native Korean speakers between 18 and 50 years of age with English as a second language may be eligible for this study. Three groups of individuals will be enrolled: 1) less fluent bilinguals - those who have lived in the United States for at least 1, but less than 2 years and studied English after age 12 and who have a TOEFL (Test of English as a Foreign Language) score above 550; 2) fluent bilinguals with early acquisition - those who were exposed to English before age 7 and lived in the United States after that; and 3) fluent bilinguals with late acquisition - those who were exposed to English after age 12 and lived in the United States after age 10. People with a history of head injury or neurological or thought disorder, left-handed people, and people who cannot read the material used in the study will be excluded from the study.

Participants will undergo magnetic resonance imaging (MRI) scanning while reading words in English or Korean; while translating from one language to the other; and while answering questions about the meaning of words in each language. MRI uses a strong magnetic field to image brain tissue. The patient lies on a table that slides into a narrow metal cylinder, which is the scanner. The head is restrained gently with foam padding to limit movement. The patient can see out of the scanner through a mirror and is in contact with the technician via an intercom at all times during the procedure. The scans measures blood flow to different parts of the brain, providing information about what brain regions are being used during the tasks performed. Another scan will be done to obtain a detailed picture of the brain's structure.

This study will evaluate the usefulness of MRI in identifying brain areas involved in processing different languages and increase knowledge about how illness affects brain function. It may help plan treatment for bilingual patients who must undergo brain surgery for uncontrolled epilepsy or who have a neurological disorder affecting different languages with varying degrees.

Detailed Description This protocol will use functional magnetic resonance imaging (fMRI) to examine the localization of verbal working memory and translation systems in normal volunteers who speak English as a second language. Several important issues in areas such as language acquisition, cortical plasticity, and bilingualism will be advanced by an increased understanding of how multiple languages are represented in the brain. There are also an increasing number of bilingual patients who need to undergo surgical intervention, particularly for uncontrolled epilepsy, or suffer from a variety of neurological disorders affecting different languages to varying degrees. It is very important to accurately assess and localize language functions in these patients. This study will identify cortical areas activated by the immediate translation of words and sentences between native and second languages, as well as differences in verbal working memory systems between two languages. It will also evaluate differences in verbal working memory and translation systems among subjects with different proficiency and different age at acquisition of their second language. This study will advance our understanding of the cortical representation that underlies multiple language functions.
Study Type Observational
Study Design Not Provided
Target Follow-Up Duration Not Provided
Biospecimen Not Provided
Sampling Method Not Provided
Study Population Not Provided
Condition
  • Brain Disorder
  • Healthy
Intervention Not Provided
Study Groups/Cohorts Not Provided
Publications *

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruitment Information
Recruitment Status Completed
Enrollment
 (submitted: June¬†23,¬†2005)
63
Original Enrollment Same as current
Study Completion Date May 2002
Primary Completion Date Not Provided
Eligibility Criteria

LESS-FLUENT BILINGUALS:

Native Korean speakers who have lived in the United States for at least one, but less than two years and have studied English after the age of 12.

TOEFL (Test of English as a Foreign Language) score above 550.

FLUENT BILINGUALS WITH EARLY ACQUISITION:

Native Korean speakers who have been exposed to English before the age of 7 and have lived in the US after that.

FLUENT BILINGUALS WITH LATE ACQUISITION:

Native Korean speakers who have been exposed to English after the age of 12 and have lived in the US after that.

ALL SUBJECTS:

Ages 18-50 years old.

No history of head injury.

No history of neurological and thought disorder.

Must not take any medication with cognitive side effects.

Must not have any contraindication for fMRI (e.g. pacemaker, metallic surgical implantation, etc.).

No left-handed persons.

No persons who are unable to read the visually presented material.

Sex/Gender
Sexes Eligible for Study: All
Ages Child, Adult, Older Adult
Accepts Healthy Volunteers Yes
Contacts Contact information is only displayed when the study is recruiting subjects
Listed Location Countries United States
Removed Location Countries  
 
Administrative Information
NCT Number NCT00016510
Other Study ID Numbers 010165
01-N-0165
Has Data Monitoring Committee Not Provided
U.S. FDA-regulated Product Not Provided
IPD Sharing Statement Not Provided
Responsible Party Not Provided
Study Sponsor National Institute of Neurological Disorders and Stroke (NINDS)
Collaborators Not Provided
Investigators Not Provided
PRS Account National Institutes of Health Clinical Center (CC)
Verification Date May 2002