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Basic Mechanisms of Meditation and Cardiovascular Disease in Older Blacks

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00010530
First Posted: February 5, 2001
Last Update Posted: December 7, 2009
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
National Center for Complementary and Integrative Health (NCCIH)
February 2, 2001
February 5, 2001
December 7, 2009
September 1999
July 2006   (Final data collection date for primary outcome measure)
Not Provided
Not Provided
Complete list of historical versions of study NCT00010530 on ClinicalTrials.gov Archive Site
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Basic Mechanisms of Meditation and Cardiovascular Disease in Older Blacks
Basic Mechanisms of Meditation and Cardiovascular Disease in Older Blacks
The purpose of this study is to evaluate the effects of meditation on older African Americans with documented cardiovascular disease (CVD).
Cardiovascular disease (CVD) is the leading cause of death and disability in older African Americans, and accounts for 40% of the disproportionate risk for mortality observed in African Americans compared to white Americans. The majority of CVD patients experience acute cardiac events, many sudden and unexpected, despite conventional treatment of their disease and associated traditional risk factors. The pathophysiologic basis of these cardiac events is not fully established, but substantial evidence indicates that psychosocial stress and the sympathetic nervous system have adverse effects on both vasomotor function and long-term autonomic balance. Recent advances in the understanding of the pathophysiology of acute cardiac events-specifically, the roles that arterial vasomotor dysfunction and sympathetic nervous system imbalance play in the pathophysiology of such acute events-provide a platform for a new mechanistic investigation of the interplay of psychosocial and environmental stress and CVD. Preliminary evidence demonstrating elevated peripheral vasoconstriction due to stress-mediated sympathetic nervous system response in African Americans further suggests that these mechanisms are particularly relevant in this group.
Interventional
Phase 1
Allocation: Randomized
Masking: Single
Primary Purpose: Treatment
Cardiovascular Diseases
Procedure: Meditation
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
Not Provided
July 2006
July 2006   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • African-American (self-identified)
  • Local residence
  • Able to participate
  • Coronary artery disease by MI, CABG, PTCA (>3 months prior), or angiography
  • Consent and referring MD approval
Sexes Eligible for Study: All
65 Years and older   (Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
United States
 
 
NCT00010530
P50AT000082-01P1( U.S. NIH Grant/Contract )
P50AT000082-01 ( U.S. NIH Grant/Contract )
P50AT000082-02 ( U.S. NIH Grant/Contract )
Yes
Not Provided
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National Center for Complementary and Integrative Health (NCCIH)
Not Provided
Principal Investigator: Robert H. Schneider, MD Center for Health and Aging Studies
National Center for Complementary and Integrative Health (NCCIH)
December 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP