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Role of Altered CD40-Ligand Gene Transcription in Systemic Lupus Erythematosus

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified December 2003 by National Center for Research Resources (NCRR).
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00008749
First Posted: January 18, 2001
Last Update Posted: December 9, 2005
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Arthritis Foundation
Information provided by:
National Center for Research Resources (NCRR)
January 16, 2001
January 18, 2001
December 9, 2005
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No Changes Posted
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Role of Altered CD40-Ligand Gene Transcription in Systemic Lupus Erythematosus
Role of Altered CD40-Ligand Gene Transcription in Systemic Lupus Erythematosus
Systemic lupus erythematosus is an often devastating autoimmune disease which affects 1 in 2,000 women in the United States. Recently, several research laboratories have reported that a protein, named CD40-ligand (CD154), is overexpressed by a subset of white blood cells, called lymphocytes, in patients with lupus. Expression of CD154 appears critical to the generation of antibodies that cause disease in lupus. Blocking CD154 interactions in the immune system has been shown to decrease disease activity in animal models of lupus. We propose to study the regulation of CD154 in patients with lupus in hopes of inhibiting its abnormal and deleterious expression.
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Observational
Observational Model: Case Control
Observational Model: Natural History
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Lupus Erythematosus, Systemic
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Unknown status
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Inclusion:

A diagnosis of systemic lupus erythematosus

Sexes Eligible for Study: All
13 Years and older   (Child, Adult, Senior)
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
 
NCT00008749
NCRR-M01RR00240-1736
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National Center for Research Resources (NCRR)
Arthritis Foundation
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National Center for Research Resources (NCRR)
December 2003