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Molecular Genetics of Schizophrenia

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00006418
First Posted: October 26, 2000
Last Update Posted: April 2, 2014
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
National Institute of Mental Health (NIMH)
Information provided by:
NorthShore University HealthSystem
October 25, 2000
October 26, 2000
April 2, 2014
September 2003
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Complete list of historical versions of study NCT00006418 on ClinicalTrials.gov Archive Site
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Molecular Genetics of Schizophrenia
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This study will create a DNA collection with blood samples from families with at least two siblings who have schizophrenia symptoms. This collection will help scientists identify genes that predispose people to schizophrenia.
Each site will recruit individuals in a large geographic area, and use efficient ascertainment strategies and assessment procedures in order to maximize the number collected. Subjects thought to have schizophrenia will be assessed by personal and family interviews and a review of medical records. Diagnoses will be made by consensus best-estimate procedures. Blood specimens will be obtained from all individuals with schizophrenia or schizoaffective disorder plus their available parents and also the control individuals. A clinical self-assessment will be administered to each control subject. The assessment will include validated self-assessments of lifetime major depression, anxiety disorders, and substance use, and self-reported history of bipolar or psychotic symptoms. Permanent cell lines will be created and DNA extracted at the NIMH-sponsored Center for Genetic Studies. At the end of the four-year project period, biological materials and blinded pedigree and clinical data will be made available to the scientific community for genetic studies of schizophrenia and related disorders. The control sample will, however, be released in a staggered fashion, twice during each fiscal year, to start during the 2nd year of recruitment. The informed consent for controls includes consent for specimens to be used in research on the genetics of any medical disorder. In years 3 and 4, we will undertake association analyses. Power analyses suggest that this study will have excellent power to detect loci associated with genes with relatively small etiologic effects. Data derived from this study will potentially have applications for the treatment and prevention of schizophrenia.
Observational
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Schizophrenia
Procedure: DNA collection
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
10800
August 2007
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Inclusion Criteria:

  • Individuals thought to have schizophrenia or schizoaffective disorder, be the parent of such an individual, or be in the matched control group of unrelated individuals not thought to have schizophrenia or schizoaffective disorder

Exclusion Criteria:

  • Unable to give informed consent to all aspects of the study
  • Psychotic disorder judged to be secondary to substance use, psychotic disorder that appears to be secondary to a known medical or neurological disorder, or severe mental retardation
Sexes Eligible for Study: All
18 Years and older   (Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
Australia,   United States
 
 
NCT00006418
R01MH059571( U.S. NIH Grant/Contract )
R01MH059571 ( U.S. NIH Grant/Contract )
R01MH059588 ( U.S. NIH Grant/Contract )
R01MH060870 ( U.S. NIH Grant/Contract )
R01MH059565 ( U.S. NIH Grant/Contract )
R01MH059566 ( U.S. NIH Grant/Contract )
R01MH060879 ( U.S. NIH Grant/Contract )
R01MH059586 ( U.S. NIH Grant/Contract )
R01MH061675 ( U.S. NIH Grant/Contract )
R01MH059587 ( U.S. NIH Grant/Contract )
DNBBS 7G-GRR
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NorthShore University HealthSystem
National Institute of Mental Health (NIMH)
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NorthShore University HealthSystem
November 2005