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Genetics of Coronary Artery Disease in Alaskan Natives (GOCADAN)

This study has been completed.
Sponsor:
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI)
ClinicalTrials.gov Identifier:
NCT00006192
First received: August 31, 2000
Last updated: July 28, 2016
Last verified: May 2009

August 31, 2000
July 28, 2016
August 2000
December 2005   (final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT00006192 on ClinicalTrials.gov Archive Site
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Genetics of Coronary Artery Disease in Alaskan Natives (GOCADAN)
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To document cardiovascular disease and cardiovascular disease risk factors among 1,200 Native Alaskans who are members of approximately 40 families.

BACKGROUND:

There are many compelling reasons to study heart disease in the Native Alaskans. These Eskimo villages are remote and isolated. The traditional lifestyle is being eroded by mechanization and a westernized diet. There has been relatively little outside genetic influence and they are, like the American Indians of the lower 48 states, beginning to show a marked acceleration in the prevalence of atherosclerosis and coronary artery disease.

DESIGN NARRATIVE:

The study is a family-based, cross sectional study. Recognized and emerging risk factors and prevalent cardiovascular disease are documented in each individual through a standardized interview, physical exam, laboratory measurements, carotid ultrasound, ECG, and a review of centralized medical records. Assays will be made of contemporary samples and serum specimens stored at the Anchorage Center CDC antedating this study (10 to 20 years ago) for specific markers of inflammation and serologic responses. Through a ten-centimorgan genetic map, attempts will be made to find specific genes that relate to cardiovascular disease.

The study uses standard methods to assess risk factors relating to lipid metabolism, hypertension, and diabetes mellitus. Importantly, the study also uses state-of-the-art methods for detection of infectious disease exposure, specifically to C. pneumoniae, cytomegalovirus, and other infectious agents hypothesized to play a role in atherogenesis. A case-control age-matched design is used to analyze the infectious disease burden.

Observational
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  • Heart Diseases
  • Cardiovascular Diseases
  • Atherosclerosis
  • Hypertension
  • Diabetes Mellitus
  • Coronary Arteriosclerosis
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
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December 2005
December 2005   (final data collection date for primary outcome measure)
No eligibility criteria
Both
18 Years to 100 Years   (Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
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NCT00006192
910, U01HL064244
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National Heart, Lung, and Blood Institute (NHLBI)
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Investigator: Giacomo Ruotolo Medstar Health Research Institute
National Heart, Lung, and Blood Institute (NHLBI)
May 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP