Visceral Fat, Metabolic Rate, and CHD Risk in Young Adults
|ClinicalTrials.gov Identifier: NCT00005388|
Recruitment Status : Completed
First Posted : May 26, 2000
Last Update Posted : February 18, 2016
|First Submitted Date||May 25, 2000|
|First Posted Date||May 26, 2000|
|Last Update Posted Date||February 18, 2016|
|Study Start Date||September 1995|
|Primary Completion Date||Not Provided|
|Current Primary Outcome Measures||Not Provided|
|Original Primary Outcome Measures||Not Provided|
|Change History||Complete list of historical versions of study NCT00005388 on ClinicalTrials.gov Archive Site|
|Current Secondary Outcome Measures||Not Provided|
|Original Secondary Outcome Measures||Not Provided|
|Current Other Outcome Measures||Not Provided|
|Original Other Outcome Measures||Not Provided|
|Brief Title||Visceral Fat, Metabolic Rate, and CHD Risk in Young Adults|
|Official Title||Not Provided|
|Brief Summary||To measure visceral (intraabdominal) fat by computerized tomography (CT) scan and to measure resting metabolic rate by indirect calorimetry in 400 CARDIA subjects, ages 28-40 years (100 of each race/gender group) from the Oakland, California and Birmingham, Alabama centers.|
The prevalence of obesity increased markedly in the United States from the 1960's to the 1980's, and varied by race and gender with particularly high rates of obesity among Black women. Reasons for the ethnic differences in the prevalence of obesity were not understood. This cross-sectional study was performed in conjunction with the 10-year follow-up examination for the Coronary Artery Risk Development in Young Adults (CARDIA) study, an NHLBI-funded longitudinal study of development of risk factors for coronary heart disease (CHD) in young black and white adults.
This study represented a unique opportunity to investigate factors that may influence the development of obesity, to better understand the relationship between obesity and cardiovascular risk factors, and to increase understanding of racial differences in adiposity.
The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.
The cross-sectional study tested the hypothesis that visceral adipose tissue, the component of fat considered to be most strongly related to coronary heart disease (CHD) risk factors, differed in Black and white subjects. Specifically, the investigators proposed that Black subjects had less visceral adipose tissue for a given level of total body fat than white subjects. Further, the relationship between visceral adipose tissue and risk factors for CHD was similar in all subjects. This would explain the different relationship between obesity and CHD risk factors seen in Black vs white subjects. A second specific aim was to determine whether Black women had a lower resting energy expenditure than Black men or whites. This could explain the higher prevalence of obesity in Black women than in Black men or whites of either gender. CT scans were recorded on tape and shipped to the University of Colorado Health Sciences Center where visceral adipose tissue was quantified. Dietary intake and physical activity were measured as important covariates in the relationship between metabolic rate and adiposity, and thyroid function was measured as a determinant of resting energy expenditure. The CARDIA study provided funding for cardiovascular risk factor measurements, including blood pressure, lipids, insulin, glucose, smoking, and anthropometric measurements including dual energy absorptiometry (DEXA) measurements of total and regional body fat.
The study was renewed in 1999 through March 2004 to perform a five-year follow-up of the cohort.
|Study Design||Not Provided|
|Target Follow-Up Duration||Not Provided|
|Sampling Method||Not Provided|
|Study Population||Not Provided|
|Study Groups/Cohorts||Not Provided|
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
|Original Enrollment||Not Provided|
|Actual Study Completion Date||March 2004|
|Primary Completion Date||Not Provided|
|Eligibility Criteria||Not Provided|
|Ages||up to 100 Years (Child, Adult, Senior)|
|Accepts Healthy Volunteers||No|
|Contacts||Contact information is only displayed when the study is recruiting subjects|
|Listed Location Countries||Not Provided|
|Removed Location Countries|
|Other Study ID Numbers||4294
R01HL053359 ( U.S. NIH Grant/Contract )
|Has Data Monitoring Committee||Not Provided|
|U.S. FDA-regulated Product||Not Provided|
|IPD Sharing Statement||Not Provided|
|Responsible Party||Not Provided|
|Study Sponsor||National Heart, Lung, and Blood Institute (NHLBI)|
|PRS Account||National Heart, Lung, and Blood Institute (NHLBI)|
|Verification Date||April 2004|