Now Available: Final Rule for FDAAA 801 and NIH Policy on Clinical Trial Reporting

Prospective Study of HIV Infection in Hemophiliacs

This study has been completed.
Sponsor:
Collaborator:
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by:
Bloodworks (Puget Sound Blood Center)
ClinicalTrials.gov Identifier:
NCT00005309
First received: May 25, 2000
Last updated: February 5, 2016
Last verified: February 2016

May 25, 2000
February 5, 2016
July 1990
Not Provided
Not Provided
Not Provided
Complete list of historical versions of study NCT00005309 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Prospective Study of HIV Infection in Hemophiliacs
Not Provided
To examine mechanisms of individual differences in the progression of HIV infection in hemophiliacs.

BACKGROUND:

In the late 1980s, hemophiliacs were transfused with a variety of blood products, including large amounts of cryoprecipitate. In comparison to other cohorts, hemophiliacs are CMV(-), resulting in a comparison group for the study of this virus as a potential cofactor. In contrast, non A, non-B hepatitis is common in comparison to other cohorts, and preliminary data prior to 1990 suggested that this chronic disease predisposes to more rapid progression of HIV infection.

DESIGN NARRATIVE:

Disease-free survival rates were determined in HIV-infected hemophiliacs. The effects of co-factors such as intensive transfusion, concomitant cytomegalovirus or chronic NANB hepatitis infection were ascertained. Host-virus interaction was assessed through the use of plasma cultures, specific antibody titers, and markers of immune changes detected by flow cytometry and immune function assays. The immunology of asymptomatic stable infection was investigated. The safety of volunteer donor blood products was determined in seronegative patients exposed to over 50,000 donors yearly and the risk of sexual transmission of HIV to spouses of seropositive patients was monitored.

Observational
Not Provided
Not Provided
Not Provided
Not Provided
Not Provided
  • Acquired Immunodeficiency Syndrome
  • HIV Infections
  • Blood Disease
  • Hemophilia A
  • Hepatitis, Viral, Human
  • Blood Transfusion
  • Cytomegalovirus Infections
Not Provided
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
Not Provided
March 1995
Not Provided
No eligibility criteria
Male
up to 100 Years   (Child, Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
Not Provided
 
NCT00005309
3012, R01HL043512
Not Provided
Not Provided
Not Provided
Not Provided
Bloodworks (Puget Sound Blood Center)
National Heart, Lung, and Blood Institute (NHLBI)
Investigator: George Gjerset Bloodworks (Puget Sound Blood Center)
Bloodworks (Puget Sound Blood Center)
February 2016

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP