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Omega-3 Fatty Acids in Treating Patients With Advanced Cancer Who Have Significant Weight Loss

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ClinicalTrials.gov Identifier: NCT00003077
Recruitment Status : Completed
First Posted : October 22, 2003
Last Update Posted : July 13, 2016
Sponsor:
Collaborator:
National Cancer Institute (NCI)
Information provided by (Responsible Party):
Alliance for Clinical Trials in Oncology

Tracking Information
First Submitted Date  ICMJE November 1, 1999
First Posted Date  ICMJE October 22, 2003
Last Update Posted Date July 13, 2016
Study Start Date  ICMJE October 1995
Actual Primary Completion Date July 2004   (Final data collection date for primary outcome measure)
Current Primary Outcome Measures  ICMJE
 (submitted: July 6, 2015)
survival [ Time Frame: up to 4 months ]
Original Primary Outcome Measures  ICMJE Not Provided
Change History
Current Secondary Outcome Measures  ICMJE Not Provided
Original Secondary Outcome Measures  ICMJE Not Provided
Current Other Pre-specified Outcome Measures Not Provided
Original Other Pre-specified Outcome Measures Not Provided
 
Descriptive Information
Brief Title  ICMJE Omega-3 Fatty Acids in Treating Patients With Advanced Cancer Who Have Significant Weight Loss
Official Title  ICMJE Phase I/II Trial of Omega-3 Fatty Acids for Cancer Cachexia
Brief Summary

RATIONALE: Omega-3 fatty acids are used by the body for energy and tissue development and may be an effective treatment for patients with advanced cancer who are unable to maintain their body weight.

PURPOSE: Phase I/II trial to study the effectiveness of omega-3 fatty acids in treating patients with advanced cancer who have significant weight loss.

Detailed Description

OBJECTIVES:

  • Determine whether omega-3 fatty acids will reverse weight loss in advanced cancer patients with cachexia.
  • Determine the maximum tolerated dose (MTD) of omega-3 fatty acids in these patients (phase I completed 12/1999).
  • Determine whether omega-3 fatty acids will result in an antitumor response.

OUTLINE: This is a randomized, stratified, dose escalation study. Patients are stratified by the extent of weight loss (2-5 percent or greater than 5 percent in the past month).

Patients receive omega-3 fatty acids orally in two equal doses with/after breakfast and lunch for 4 months or until weight loss is observed.

Dose is escalated in cohorts of two patients, although dose escalation is allowed in individual patients. The maximum tolerated dose (MTD) is defined as the highest dose level at which no greater than one-third of the patients treated, including escalated patients from a lower dose, experience grade 3 or worse toxicity (phase I completed 12/1999).

Study Type  ICMJE Interventional
Study Phase  ICMJE Phase 1
Phase 2
Study Design  ICMJE Allocation: N/A
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Supportive Care
Condition  ICMJE
  • Leukemia
  • Lymphoma
  • Multiple Myeloma and Plasma Cell Neoplasm
Intervention  ICMJE Dietary Supplement: omega-3 fatty acid
Study Arms  ICMJE Experimental: Omega-3 fatty acid

Patients receive omega-3 fatty acids orally in two equal doses with/after breakfast and lunch for 4 months or until weight loss is observed.

Dose is escalated in cohorts of two patients, although dose escalation is allowed in individual patients. Patients are evaluated for cachexia response every 2 weeks, and tumor response every 4 weeks for a maximum of 4 months. If no response of cachexia or tumor after a 2 month period, patients will be discontinued from study. Patients will be followed for survival post-treatment.

Intervention: Dietary Supplement: omega-3 fatty acid
Publications * Burns CP, Halabi S, Clamon G, Kaplan E, Hohl RJ, Atkins JN, Schwartz MA, Wagner BA, Paskett E. Phase II study of high-dose fish oil capsules for patients with cancer-related cachexia. Cancer. 2004 Jul 15;101(2):370-8.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruitment Information
Recruitment Status  ICMJE Completed
Actual Enrollment  ICMJE
 (submitted: February 15, 2007)
63
Original Enrollment  ICMJE Not Provided
Actual Study Completion Date  ICMJE November 2004
Actual Primary Completion Date July 2004   (Final data collection date for primary outcome measure)
Eligibility Criteria  ICMJE

DISEASE CHARACTERISTICS:

  • Histologically or cytologically proven advanced cancer not amenable to curative therapy (solid tumors and hematologic malignancies eligible except primary and metastatic brain tumors)
  • Cachexia (weight loss at least 2 percent within a one month period)

PATIENT CHARACTERISTICS:

Age:

  • 18 and over

Performance Status:

  • CALBG 0-2

Life Expectancy:

  • At least 2 months

Hematopoietic:

  • Granulocytes greater than 1,000/mm3
  • Platelet count greater than 75,000/mm3
  • Hemoglobin greater than 8 mg/dL

Hepatic:

  • AST less than 3 times upper limit of normal (ULN)
  • Alkaline phosphatase less than 3 times ULN
  • Bilirubin less than 1.5 times ULN

Renal:

  • BUN less than 1.5 times ULN
  • Creatinine less than 1.5 times ULN

Cardiovascular:

  • No congestive heart failure requiring diuretics within less than 6 months
  • No uncontrolled or severe cardiovascular disease within less than 6 months
  • No myocardial infarction within less than 6 months

Other:

  • Not pregnant nor contemplating pregnancy during study
  • Negative pregnancy test
  • No uncontrolled hypercalcemia
  • No metabolic disorders (hyperthyroidism)
  • No poorly controlled diabetes
  • No peripheral edema or ascites requiring diuretics
  • No enteric fistulas, with tracheobronchial fistulas or with aspiration
  • No esophageal or bowel obstruction that would preclude eating
  • Free T4 within normal range
  • No serious medical illness
  • No psychosis
  • No uncontrolled bacterial, viral, or fungal infections
  • No active uncontrolled duodenal ulcers
  • Above laboratory values required unless bone marrow, liver, kidney, or splenic involvement by tumor is documented

PRIOR CONCURRENT THERAPY:

Biologic therapy:

  • Not specified

Chemotherapy:

  • Prior and concurrent chemotherapy allowed

Endocrine therapy:

  • No concurrent steroids such as dronabinol or megestrol acetate (except for adrenal failure)

Radiotherapy:

  • No prior or concurrent radiotherapy to abdomen or pelvis

Surgery:

  • Greater than 3 weeks since major surgery
  • Greater than 1 week since minor surgery

Other:

  • No concurrent diuretics
Sex/Gender  ICMJE
Sexes Eligible for Study: All
Ages  ICMJE 18 Years to 120 Years   (Adult, Older Adult)
Accepts Healthy Volunteers  ICMJE No
Contacts  ICMJE Contact information is only displayed when the study is recruiting subjects
Listed Location Countries  ICMJE United States
Removed Location Countries  
 
Administrative Information
NCT Number  ICMJE NCT00003077
Other Study ID Numbers  ICMJE CALGB-9473
U10CA031946 ( U.S. NIH Grant/Contract )
CLB-9473
NCI-P97-0097
CDR0000065766 ( Registry Identifier: NCI Physician Data Query )
Has Data Monitoring Committee No
U.S. FDA-regulated Product Not Provided
IPD Sharing Statement  ICMJE Not Provided
Responsible Party Alliance for Clinical Trials in Oncology
Study Sponsor  ICMJE Alliance for Clinical Trials in Oncology
Collaborators  ICMJE National Cancer Institute (NCI)
Investigators  ICMJE
Study Chair: C. Patrick Burns, MD Holden Comprehensive Cancer Center
PRS Account Alliance for Clinical Trials in Oncology
Verification Date July 2016

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP