Study of the Effects of Temperature on Metabolism in Human Muscle

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00001753
Recruitment Status : Completed
First Posted : December 10, 2002
Last Update Posted : March 4, 2008
Information provided by:
National Institutes of Health Clinical Center (CC)

November 3, 1999
December 10, 2002
March 4, 2008
September 1998
Not Provided
Not Provided
Not Provided
Complete list of historical versions of study NCT00001753 on Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
Study of the Effects of Temperature on Metabolism in Human Muscle
Study of Temperature Effects on Skeletal Muscle Aerobic Energy Metabolism

This study will examine the role of temperature in changing energy metabolism in human muscle. In order to do this, researchers will use magnetic resonance imaging (MRI) to provide information about how parts of muscle operate during exercise.

Magnetic resonance imaging (MRI) is a diagnostic tool that creates high quality images of the human body without the use of X-ray (radiation). In this study, MRI will be used to measure the temperature and energy level of specific muscles during rest and exercise. In addition, the muscles being tested will be heated and cooled to see if temperature directly affects levels of energy in muscle.

This study will examine the role of temperature in modulating aspects of energy metabolism in human skeletal muscle. Tests will be conducted at rest and during concentric dorsiflexion exercise of the Tibialis anterior (TA) muscle using an existing custom-designed dynamometer in conjunction with mild local heating and cooling. Magnetic resonance spectroscopy (MRS), performed in a 4-tesla whole-body NMR system, will be used to non-invasively measure muscle temperature and energy-state. Specifically these tests will assess the extent to which temperature changes occur during aerobic exercise and how small temperature changes affect mitochondrial function in-vivo.
Phase 1
Primary Purpose: Treatment
Procedure: Magnetic resonance imaging
Not Provided
Fowler MD, Ryschon TW, Wysong RE, Combs CA, Balaban RS. Normalized metabolic stress for 31P-MR spectroscopy studies of human skeletal muscle: MVC vs. muscle volume. J Appl Physiol (1985). 1997 Sep;83(3):875-83.

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
Same as current
November 2000
Not Provided

Ages 18 to 50.

Male and female subjects.

Capable of giving informed consent.

Healthy normal volunteers.

No cardiac pacemaker of implantable defibrillator.

No aneurysm clip.

No neural stimulator (e.g. TENS-unit).

No ear implant of any type.

No metal in the eye (e.g. from machining).

No implanted device (e.g. insulin pump, drug infusion device).

No metallic foreign body, shrapnel, or bullet.

Sexes Eligible for Study: All
Child, Adult, Older Adult
Contact information is only displayed when the study is recruiting subjects
United States
Not Provided
Not Provided
Not Provided
Not Provided
National Heart, Lung, and Blood Institute (NHLBI)
Not Provided
Not Provided
National Institutes of Health Clinical Center (CC)
August 1999

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP