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Diagnosis and History Study of Patients With Different Neurological Conditions

This study is currently recruiting participants.
Verified November 2, 2017 by National Institutes of Health Clinical Center (CC) ( National Institute of Neurological Disorders and Stroke (NINDS) )
Sponsor:
ClinicalTrials.gov Identifier:
NCT00001367
First Posted: November 4, 1999
Last Update Posted: November 7, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
Information provided by (Responsible Party):
National Institutes of Health Clinical Center (CC) ( National Institute of Neurological Disorders and Stroke (NINDS) )
November 3, 1999
November 4, 1999
November 7, 2017
September 1, 1993
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Complete list of historical versions of study NCT00001367 on ClinicalTrials.gov Archive Site
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Diagnosis and History Study of Patients With Different Neurological Conditions
Diagnosis and Natural History Protocol for Patients With Different Neurological Conditions

The goal of this study is to diagnose and follow patients with disorders of movement control. Patients participating in this study will undergo routine laboratory tests and examinations in order to monitor their condition.

Doctors at the NIH will work in cooperation with each patient's primary care physician. There will be no use of investigational treatments in this study.<TAB>

Objective:

This protocol is a screening protocol, which allows for evaluation of patients and families where neurological conditions are present for enrollment into other studies. It is also a teaching and training instrument for the MNB fellows, allowing them to gain expertise in the evaluation and treatment of patients. Finally, it will be used to screen healthy volunteers to create a pool of potential future HV matches for HMCS protocols.

Study population:

The following population groups may participate:

  • Subjects with neurological disorders who are 2 years old or older,
  • Family members who are 2 years old or older of people with a neurological disorder
  • Healthy volunteers who are 18 years old or older.
  • National Institutes of Health (NIH) employees (other than those employed by HMCS in NINDS) may participate.

Design:

The goal is to screen patients with neurological conditions and family members of patients with neurological conditions for enrollment in additional research protocols. No investigational treatments will be administered on this protocol and the NIH physicians will be playing a consultative role to the patient s primary physician.

We will also screen healthy volunteers to create a pool of potential future HV matches for other HMCS protocols.

Outcome measures:

This is a natural history screening protocol to evaluate patients with neurological disorders and their family members, and to screen healthy volunteers for to create a pool of potential future HV matches other HMCS protocols. Therefore, there is no outcome measure.

Observational
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Nervous System Disease
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
4100
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  • INCLUSION CRITERIA:
  • Patients with neurological disorders and subjects with a family history of neurological conditions OR
  • Healthy volunteers: People age 18 or older who are generally in good health.

EXCLUSION CRITERIA:

  • Patients <2 years old.
  • Employees of HMCS in NINDS.

EXCLUSION CRITERIA FOR MRI (patients and family members only):

We will follow the Clinical Radiology/NMR Center guidelines for MR safety. Some of the exclusions are:

  • Have non-MRI compatible metal in the body, such as a cardiac pacemaker, brain stimulator, shrapnel, surgical metal, clips in the brain or on blood vessels, cochlear implants, artificial heart valves or metal fragments in the eye as these make having an MRI unsafe.
  • Have metallic dental fillings which are likely to cause MRI artifacts
  • Unable to lie flat on the back for the expected length of the experiment, up to 30 mins.
  • Uncomfortable being in a small space for the expected length of the experiment, up to 30 mins.
  • Pregnancy.
Sexes Eligible for Study: All
2 Years and older   (Child, Adult, Senior)
Yes
Contact: Elaine P Considine, R.N. (301) 435-8518 considinee@ninds.nih.gov
Contact: Mark Hallett, M.D. (301) 496-9526 hallettm@ninds.nih.gov
United States
 
 
NCT00001367
930202
93-N-0202
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National Institutes of Health Clinical Center (CC) ( National Institute of Neurological Disorders and Stroke (NINDS) )
National Institute of Neurological Disorders and Stroke (NINDS)
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Principal Investigator: Mark Hallett, M.D. National Institute of Neurological Disorders and Stroke (NINDS)
National Institutes of Health Clinical Center (CC)
November 2, 2017