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Comparing Magnetic Resonance Imaging/Spectroscopy Techniques

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ClinicalTrials.gov Identifier: NCT00001219
Recruitment Status : Recruiting
First Posted : November 4, 1999
Last Update Posted : September 24, 2018
Sponsor:
Information provided by (Responsible Party):
National Institutes of Health Clinical Center (CC)

November 3, 1999
November 4, 1999
September 24, 2018
June 18, 1987
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Success of new sequences [ Time Frame: 10 scan comparison ]
clinically meaningful pulse sequence improvements
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Complete list of historical versions of study NCT00001219 on ClinicalTrials.gov Archive Site
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Comparing Magnetic Resonance Imaging/Spectroscopy Techniques
Magnetic Resonance Imaging at 1.5 and 3.0 Tesla

Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) are diagnostic tests that allow researchers to look at different chemical properties of tissue. Magnetic resonance imaging and spectroscopy studies can be used to gather or evaluate information about various aspects of patient s bodies or to monitor changes in the biochemistry and physiology of patient s bodies.

Unlike other diagnostic techniques (CT scan and PET scan) MRI and MRS do not use ionizing radiation. Some studies have shown that MRI is more effective at distinguishing normal parts of the anatomy from abnormal anatomy, especially in the brain. MRI has become the diagnostic test of choice for evaluating patient with multiple sclerosis.

The purpose of this study is to evaluate normal volunteers and patients with a variety of diseases with magnetic resonance imaging. Researchers will attempt different magnetic resonance imaging methods and techniques as well as different levels of magnetic strength.

Background:

MRI is a constantly evolving imaging modality. Pulse sequences are often modified to improve their performance. However, many of these changes have not yet been approved by the FDA and therefore, are not considered standard of care. Some of these sequences require the use of new types of imaging coils, which are also investigational.

Objectives:

The major purpose of this protocol is to inform patients undergoing MR scans in the Clinical Center that they be scanned with MRI sequences and/or coils which may or may not be FDA approved and to get the patient s consent for this. This is not a formal research study since specific disease entities and specific pulse sequences are not studied in a systematic way. Rather, the purpose is to give NIH patients access to gradual improvements in MR technology that would otherwise not be available to them.

Eligibility:

All patients who, by virtue of the NIH protocol in which they are enrolled, qualify for MRI will be eligible for participation in this protocol.

Design:

Up to 99,999 participants will be enrolled in this study.

Observational
Observational Model: Cohort
Time Perspective: Prospective
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Probability Sample
All patients who by virtue of the NIH protocol in which they are enrolled who qualify for MRI in the Clinical Center, are eligible to participate if (1) Stable for MRI (2) Informed Consent is obtained
MRI Scans
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
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99999
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  • INCLUSION CRITERIA:
  • All patients undergoing MRI in the Clinical Center.
  • Patients must be able to provide informed consents.

EXCLUSION CRITERIA:

  • Contraindications to MRI.
  • Inability to understand consent form or consent process and the absence of a suitable guardian.
  • Adults who are or may not be able to consent
  • Patients in whom the scan must be performed quickly, i.e. those patients under anesthesia, anxious patients, those requiring emergency medical care, or others in which it is deemed inappropriate to prolong a study.
  • Refusal to Participate.
  • Pregnant women and fetuses
  • Neonates
Sexes Eligible for Study: All
up to 99 Years   (Child, Adult, Older Adult)
Yes
Contact: John A Butman, M.D. (301) 402-5827 jbutman@nih.gov
United States
 
 
NCT00001219
870091
87-CC-0091
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National Institutes of Health Clinical Center (CC)
National Institutes of Health Clinical Center (CC)
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Principal Investigator: John A Butman, M.D. National Institutes of Health Clinical Center (CC)
National Institutes of Health Clinical Center (CC)
April 12, 2018