Evaluation of the Genetics of Bipolar Disorder

This study is currently recruiting participants. (see Contacts and Locations)
Verified January 2016 by National Institutes of Health Clinical Center (CC)
Sponsor:
Information provided by (Responsible Party):
National Institutes of Health Clinical Center (CC) ( National Institute of Mental Health (NIMH) )
ClinicalTrials.gov Identifier:
NCT00001174
First received: November 3, 1999
Last updated: May 11, 2016
Last verified: January 2016

November 3, 1999
May 11, 2016
August 1980
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Complete list of historical versions of study NCT00001174 on ClinicalTrials.gov Archive Site
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Evaluation of the Genetics of Bipolar Disorder
Bipolar Genetics: A Collaborative Study
This study looks to identify genes that may affect a person's chances of developing bipolar disorder (BP) and related conditions.

Bipolar affective disorder is a severe, heritable condition affecting about one percent of

the population. The mode of inheritance is poorly understood and probably involves multiple loci of small to moderate effect. In this project, we use genetic mapping and sequencing methods to identify genetic markers and variations that contribute to the risk of bipolar disorder. Individuals diagnosed with bipolar disorder are studied, along with their relatives. Phenotypic information obtained from clinical interviews and family history is correlated with genotypic information obtained from genetic marker and sequencing methods. The goal is to identify genes involved in bipolar disorder and related conditions so that better methods of diagnosis, treatment, and prevention can be developed.

Observational
Time Perspective: Retrospective
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  • Mania
  • Bipolar, Disorder
  • Depression
  • Mood Disorder
  • Schizoaffective
  • Manic Depression
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
4000
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  • INCLUSION CRITERIA:

Age > 18 yr

Able to provide informed consent

Diagnosed with bipolar disorder not attributable to substance abuse, neurological disease; or a 1st or 2nd degree relative of an enrolled participant

Able to safely provide a blood or saliva sample

EXCLUSION CRITERIA:

Active alcohol or substance abuse

Both
18 Years to 85 Years
Yes
Contact: Joan Mallinger, Ph.D. (301) 594-0576 mallingerj@mail.nih.gov
Contact: Francis J McMahon, M.D. (301) 451-4453 mcmahonf@mail.nih.gov
United States
 
NCT00001174
800083, 80-M-0083
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National Institutes of Health Clinical Center (CC) ( National Institute of Mental Health (NIMH) )
National Institute of Mental Health (NIMH)
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Principal Investigator: Francis J McMahon, M.D. National Institute of Mental Health (NIMH)
National Institutes of Health Clinical Center (CC)
January 2016

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP