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Exercise Training and Plasma Lipoproteins in Man

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00000519
First Posted: October 28, 1999
Last Update Posted: March 17, 2014
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by (Responsible Party):
Stanford University
October 27, 1999
October 28, 1999
March 17, 2014
July 1982
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Complete list of historical versions of study NCT00000519 on ClinicalTrials.gov Archive Site
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Exercise Training and Plasma Lipoproteins in Man
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To determine the effects in moderately obese subjects of weight loss by combined dieting and exercise training on risk factors for coronary artery disease including lipoprotein lipids, apoproteins and blood pressure.

BACKGROUND:

Evidence appears to be fairly conclusive that obesity has adverse effects on health and longevity when the relative body weight is 40 percent above desirable weight based on insurance industry tables of weights. The close association between obesity, hypertension, hypercholesterolemia, non-insulin dependent diabetes mellitus, an excess of certain cancers and other medical problems makes it imperative that interventions be directed to change the lifestyles and behaviors of individuals who are overweight. The Stanford Weight Control Project (SWCP) trial examined the effects of weight loss on cardiovascular disease risk factors.

The Stanford Weight Control Project (SWCP) randomized 155 overweight, sedentary, non-smoking men, aged 30-59 years, to one of three groups. Fifty-one were assigned to weight loss through dieting, 52 to weight loss through exercise, and 52 to a control, non-intervention group. Follow-up continued through July 1989.

DESIGN NARRATIVE:

Subjects were randomized to a control group, a hypocaloric National Cholesterol Education Program (NCEP) diet, or to a hypocaloric NCEP diet with exercise. One hundred nineteen of the men and 112 of the women returned for testing after one year.

Interventional
Phase 3
Allocation: Randomized
Primary Purpose: Prevention
  • Cardiovascular Diseases
  • Coronary Disease
  • Heart Diseases
  • Hypertension
  • Myocardial Ischemia
  • Obesity
  • Behavioral: diet, reducing
  • Behavioral: exercise
  • Behavioral: diet, fat-restricted
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
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Men and women, ages 25-49. Subjects were overweight with blood pressure less than 160/95 mm Hg and total cholesterol less than 260 mm/dl.
Sexes Eligible for Study: All
25 Years to 49 Years   (Adult)
No
Contact information is only displayed when the study is recruiting subjects
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NCT00000519
38
R01HL024462 ( U.S. NIH Grant/Contract )
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Stanford University
Stanford University
National Heart, Lung, and Blood Institute (NHLBI)
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Stanford University
June 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP