ClinicalTrials.gov
ClinicalTrials.gov Menu

Lack of Acute Tolerance Development to Effects of Nitrous Oxide - 4

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00000252
Recruitment Status : Completed
First Posted : September 21, 1999
Last Update Posted : May 28, 2015
Sponsor:
Collaborator:
National Institute on Drug Abuse (NIDA)
Information provided by (Responsible Party):
University of Chicago

September 20, 1999
September 21, 1999
May 28, 2015
June 1994
June 1996   (Final data collection date for primary outcome measure)
  • Psychomotor performance [ Time Frame: During inhalation ]
    Subjects will undergo psychomotor testing during 120 min inhalation session of each intervention
  • Cognitive performance [ Time Frame: During inhalation ]
    Subjects will under cognitive testing during 120 minute inhalation session of each intervention
  • Mood
  • Psychomotor performance
  • Cognitive performance
Complete list of historical versions of study NCT00000252 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Lack of Acute Tolerance Development to Effects of Nitrous Oxide - 4
Lack of Acute Tolerance Development to Effects of Nitrous Oxide
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To examine the lack of acute tolerance development to the subjective, cognitive, and psychomotor effects of nitrous oxide in healthy volunteers.
Not Provided
Interventional
Phase 2
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
  • Opioid-Related Disorders
  • Substance-Related Disorders
  • Drug: 0% N2O
  • Drug: 10% N2O
  • Drug: 20% N2O
  • Drug: 30% N2O
  • Drug: 40% N2O
  • Sham Comparator: 0% N2O
    Subjects will inhale 0% N2O
    Intervention: Drug: 0% N2O
  • Active Comparator: 10% N2O
    Subjects will inhale 10% N2O
    Intervention: Drug: 10% N2O
  • Active Comparator: 20% N2O
    Subjects will inhale 20% N2O
    Intervention: Drug: 20% N2O
  • Active Comparator: 30% N2O
    Subjects will inhale 30% N2O
    Intervention: Drug: 30% N2O
  • Active Comparator: 40% N2O
    Subjects will inhale 40% N2O
    Intervention: Drug: 40% N2O
Yajnik S, Zacny JP, Young CJ, Lichtor JL, Rupani G, Klafta JM, Coalson DW, Apfelbaum JL. Lack of acute tolerance development to the subjective, cognitive, and psychomotor effects of nitrous oxide in healthy volunteers. Pharmacol Biochem Behav. 1996 Jun;54(2):501-8.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
11
0
June 1996
June 1996   (Final data collection date for primary outcome measure)
Please contact site for information.
Sexes Eligible for Study: All
21 Years to 29 Years   (Adult)
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
 
NCT00000252
NIDA-08391-4
R01DA008391 ( U.S. NIH Grant/Contract )
R01-08391-4
Not Provided
Not Provided
Not Provided
University of Chicago
University of Chicago
National Institute on Drug Abuse (NIDA)
Principal Investigator: James Zacny, Ph.D. University of Chicago
University of Chicago
May 2015

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP