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The Findings of Magnetic Resonance Imaging in Subtypes of Tics-related Disorders

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ClinicalTrials.gov Identifier: NCT05566496
Recruitment Status : Recruiting
First Posted : October 4, 2022
Last Update Posted : October 5, 2022
Sponsor:
Information provided by (Responsible Party):
National Taiwan University Hospital

Study Description
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Brief Summary:
The findings of resting-state functional magnetic resonance imaging and diffusion spectrum imaging in subtypes of tics-related disorders

Condition or disease Intervention/treatment
Tourette Syndrome in Children Diagnostic Test: Brain MRI

Study Design
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Study Type : Observational
Estimated Enrollment : 500 participants
Observational Model: Case-Crossover
Time Perspective: Retrospective
Official Title: The Findings of Resting-state Functional Magnetic Resonance Imaging, Diffusion Spectrum Imaging, and Wideband Magnetic Resonance Imaging in Subtypes of Tics-related Disorders
Estimated Study Start Date : October 1, 2022
Estimated Primary Completion Date : August 1, 2025
Estimated Study Completion Date : December 2030

Resource links provided by the National Library of Medicine


Groups and Cohorts
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Group/Cohort Intervention/treatment
Tourette
Age less than 18 years old Diagnosed as Tourette syndrome or chronic tic disorders No other neuropsychiatric disorders
 Diagnostic Test: Brain MRI
All participants receive brain MRI evaluation and clinical evaluation of tic severity.
Healthy
Age less than 18 years old No other neuropsychiatric disorders
 Diagnostic Test: Brain MRI
All participants receive brain MRI evaluation and clinical evaluation of tic severity.


Outcome Measures
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Primary Outcome Measures :
  1. Difference between healthy and Tourette group [ Time Frame: 2 years after enrollment for primary evaluation ]
    Difference of MRI result between healthy and Tourette group


Eligibility Criteria
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Ages Eligible for Study:   0 Years to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
We enrolled treatment-naive Tourette syndrome or chronic tic disorder pediatric patients for Tourette group and healthy age- and gender-matched participants for healthy control
Criteria

Inclusion Criteria:

  • Age less than 18 years old
  • Diagnosed as Tourette syndrome or chronic tic disorders

Exclusion Criteria:

  • History of neuropsychiatric disorders
  • Already receive treatment for Tourette syndrome/chronic tics disorder
  • Have some device not allowed for MRI scan
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT05566496


Contacts
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Contact: Wang-Tso Lee (886)2-23123456 ext 71618 leeped@hotmail.com

Locations
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Taiwan
National Taiwan University Children Hospital Pediatric Neurology Department Recruiting
Taipei, Taiwan, 100
Contact: Wang-Tso Lee    (886)2-23123456 ext 71618    leeped@hotmail.com   
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
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Principal Investigator: Wang-Tso Lee National Taiwan University Children Hospital Pediatric neurology department
More Information
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Top of Page Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information
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Responsible Party: National Taiwan University Hospital
ClinicalTrials.gov Identifier: NCT05566496    
Other Study ID Numbers: 201503062RIND
First Posted: October 4, 2022    Key Record Dates
Last Update Posted: October 5, 2022
Last Verified: September 2022

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by National Taiwan University Hospital:
MRI
pediatric neurology
Additional relevant MeSH terms:
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Tourette Syndrome
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Tic Disorders
 Movement Disorders
Heredodegenerative Disorders, Nervous System
Neurodegenerative Diseases
Genetic Diseases, Inborn
Neurodevelopmental Disorders
Mental Disorders