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Dental Age Estimation by Different Methods in Patients With Amelogenesis Imperfecta

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ClinicalTrials.gov Identifier: NCT05343247
Recruitment Status : Recruiting
First Posted : April 25, 2022
Last Update Posted : April 25, 2022
Sponsor:
Information provided by (Responsible Party):
Yelda Kasımoğlu Eldem, Istanbul University

Brief Summary:
The aim of this study is to investigate whether there is a significant difference in dental age between children with AI and healthy controls using the Willems method, Cameriere European formula and London Atlas. If there is a significant difference in dental age between children with AI and healthy controls, it is aimed to create a new formula.

Condition or disease Intervention/treatment
Amelogenesis Imperfecta Dental Age Estimation Diagnostic Test: Willems method Diagnostic Test: Cameriere method Diagnostic Test: London Atlas method

Detailed Description:

One of the developmental enamel defects, amelogenesis imperfecta (AI), is also known as enamel hypoplasia/hypomineralization. It is a rare inherited disease that affects the enamel structure, amount and component in primary and permanent teeth, and it has been reported to be accompanied by some dental anomalies and nephrocalcinosis. Dental anomalies and nephrocalcinosis can affect tooth development, and there are limited studies examining tooth development in these individuals.Dental age is widely evaluated by pedodontists, forensic dentists and orthodontists. While a delay in tooth development may be associated with growth retardation and learning difficulties, dental age determination can also be used for forensic age determination for children whose birth information is uncertain. A clear assessment of maturation in children with continued growth is important in establishing a dental treatment plan.

Dental age is widely evaluated by pedodontists, forensic dentists and orthodontists. While a delay in tooth development may be associated with growth retardation and learning difficulties, dental age determination can also be used for forensic age determination for children whose birth information is uncertain. A clear assessment of maturation in children with continued growth is important in establishing a dental treatment plan.

There are two basic approaches to dental age determination in children:

  1. evaluation of eruption of teeth in the oral cavity,
  2. evaluation of the development and mineralization of crowns and roots on dental radiographs.

In many methods, the developmental stages of different numbers of permanent teeth are used.

The most commonly used method for determining dental age in children; is the Demirjian method that evaluates the development of seven left permanent mandibular teeth in eight stages (from A to H). Willems et al. In 2001, they modified the Demirjian method by conducting a study on the fact that it showed higher age determination in the Belgian Caucasian population. The adapted method was named the Willems method. It is stated that one of the advantages of this method is that it is a relatively simple system for determining tooth age.

One of the most widely used methods of dental age determination recently is the European formula of Cameriere et al., which is calculated based on open apex. It has been reported that this method has been tested on different population groups, and the results are accurate and reliable.

An atlas method was proposed by a group of London researchers in 2010. The Atlas shows all the teeth array images of certain age groups as a schematic series. Age determination is made by deciding which reference image matches the individual's panoramic radiography image more.

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Study Type : Observational
Estimated Enrollment : 240 participants
Observational Model: Case-Control
Time Perspective: Retrospective
Official Title: Evaluation of Whether There is a Significant Difference in Dental Age Between Children With AI and Healthy Controls Using the Willems Method, the Cameriere European Formula, and the London Atlas.
Actual Study Start Date : March 1, 2022
Estimated Primary Completion Date : June 15, 2022
Estimated Study Completion Date : August 15, 2022

Resource links provided by the National Library of Medicine


Group/Cohort Intervention/treatment
Children who applied to Istanbul U. Faculty of Dentistry, Department of Pedodontics, with AI Diagnostic Test: Willems method
Willems method measures the developmental stages of the seven left permanent mandibular teeth and is frequently used for dental age estimation. The score of each stage is allocated, and the sum of the scores provides an evaluation of the subject's dental maturity.

Diagnostic Test: Cameriere method
Cameriere et al. designed a quantitative approach through a formula based on sex and the ratio between length and apex opening measurements of each lower left tooth.

Diagnostic Test: London Atlas method
The London Atlas requires the user to assess the tooth development and eruption and then match it to one of the 31 pictures of age categories.

Healthy controls with gender-age match Diagnostic Test: Willems method
Willems method measures the developmental stages of the seven left permanent mandibular teeth and is frequently used for dental age estimation. The score of each stage is allocated, and the sum of the scores provides an evaluation of the subject's dental maturity.

Diagnostic Test: Cameriere method
Cameriere et al. designed a quantitative approach through a formula based on sex and the ratio between length and apex opening measurements of each lower left tooth.

Diagnostic Test: London Atlas method
The London Atlas requires the user to assess the tooth development and eruption and then match it to one of the 31 pictures of age categories.




Primary Outcome Measures :
  1. Investigate whether there is a significant difference in dental age between children with AI and healthy controls. [ Time Frame: Two Months ]
    If there is a significant difference in dental age between children with AI and healthy controls, it is aimed to create a new formula.



Information from the National Library of Medicine

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Ages Eligible for Study:   5 Years to 16 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
This study was conducted on gender-age matched healthy control group of children aged 5-16 years, who applied to Istanbul University Faculty of Dentistry, Department of Pedodontics, had an AI record in their anamnesis, had panoramic radiographs in the archive of the Department of Oral and Maxillofacial Radiology, Istanbul University Faculty of Dentistry.
Criteria

Inclusion Criteria:

  • 5-16 years old
  • Healthy children
  • Children with AI
  • Patients without missing left mandibular permanent teeth on panoramic radiography

Exclusion Criteria:

  • Children younger than 5 years old and older than 16 years (children that cannot be assessed by the Willems method)
  • Poor quality panoramic radiography
  • Patients who have received orthodontic treatment
  • Patients who received restorative or endodontic treatment

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT05343247


Contacts
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Contact: Yelda Kasimoglu Eldem, Assoc. Prof. 00905336233978 yelda.kasimoglu@istanbul.edu.tr

Locations
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Turkey
Istanbul University, Faculty of Dentistry Recruiting
Istanbul, Turkey
Contact: Yelda Kasimoglu Eldem, Assoc. Prof.         
Sponsors and Collaborators
Istanbul University
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Responsible Party: Yelda Kasımoğlu Eldem, Principal investigator, Istanbul University
ClinicalTrials.gov Identifier: NCT05343247    
Other Study ID Numbers: 2021/76
First Posted: April 25, 2022    Key Record Dates
Last Update Posted: April 25, 2022
Last Verified: April 2022
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Yelda Kasımoğlu Eldem, Istanbul University:
children
dental age estimation
amelogenesis imperfecta
chronological age
Additional relevant MeSH terms:
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Amelogenesis Imperfecta
Dental Enamel Hypoplasia
Tooth Abnormalities
Stomatognathic System Abnormalities
Stomatognathic Diseases
Tooth Diseases
Congenital Abnormalities