Characterizations of Gut Microbiota and Postoperative Sleep in Patients Undergoing Heart Valve Surgery With Cardiopulmonary Bypass
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The investigators designed a study to assess whether there is any change in gut microbiota and postoperative sleep before and after heart valve surgery with cardiopulmonary bypass.
Condition or disease
Heart Valve Surgery
The investigators designed a study to assess whether there is any change in gut microbiota and postoperative sleep before and after heart valve surgery with cardiopulmonary bypass. Firstly, this study aims to characterize the gut microbiota in patients with valve disease treated with surgery. Secondly, it aims to evaluate microbiota and its influence on postoperative sleep.
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Layout table for eligibility information
Ages Eligible for Study:
18 Years to 65 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
This study will characterize the gut microbiota and serum metabolites in one group of 36 patients before and after heart valve surgery
Age, 18 to 65 years old;
Patients undergoing heart valve surgery with cardiopulmonary bypass
Preoperative Pittsburgh Sleep Quality Index global scores higher than 6
Partial or complete gastrectomy
Previous esophageal surgery
Previous treated by radiotherapy or surgery
Inability to conform to the study's requirements
Body mass index exceeding 30 kg/m2
Deprivation of a right to decide by an administrative or juridical entity
Ongoing participation or participation in another study <1 month ago
Recent (< 3 months prior) use of antibiotics, probiotics, prebiotics, symbiotics, hormonal medication, laxatives, proton pump inhibitors, insulin sensitizers or traditional Chinese medicine