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Carpal Tunnel Syndrome in Patients With Psoriatic Arthritis; Ultrasonography and Magnetic Resonance Imaging Findings

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ClinicalTrials.gov Identifier: NCT05086042
Recruitment Status : Completed
First Posted : October 20, 2021
Last Update Posted : October 20, 2021
Sponsor:
Information provided by (Responsible Party):
Ezgi AKYILDIZ TEZCAN, Selcuk University

Brief Summary:
This study aimed to investigate relationship between CTS diagnosis with electrodiagnostic studies and median nerve's cross-sectional area measered by US and MRI in PsA patients.

Condition or disease Intervention/treatment
Carpal Tunnel Syndrome Psoriatic Arthritis Diagnostic Test: Ultrasonography, Magnetic resonance imaging

Detailed Description:
Carpal tunnel syndrome (CTS) is a type of entrapment neuropathy, caused by compression of the median nerve in the carpal tunnel at the wrist1. It accounts for about 90% of all entrapment neuropathies. But there is no gold standard technique for diagnosing CTS. Electrodiagnostic studies (EDS) are generally used in differential diagnosis because the symptoms may be difficult to interpret. Unfortunetely EDS has some limitations. The factors can limit EDS are that it is not comfortable for patients and physicians, may require interventional procedures, need patient cooperation, provide limited information on the etiology of CTS, time consuming, and can not be used in some patient groups such as patients with dermatological contraindications. Recent years, magnetic resonance imaging (MRI) and ultrasonography (US) have facilitated the diagnosis of CTS. The median nerve cross-sectional area (CSA) measured by US or MRI has been found to be associated with CTS. However, there are studies with conflicting results regarding the median nerve CSA in patients with rheumatic diseases. Psoriatic arthritis (PsA), a kind of rheumatic disease, occurs in up to 30% of people with psoriasis and can have serious debilitating effects on the peripheral joints, spine, tendon insertions, and fingers. To our knowlage, any study didn't assess MRI measurements of median nerve CSA in PsA patients. In this study we aimed to assess CTS's US and MRI findings in patients with PsA and compare them healty controls.

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Study Type : Observational
Actual Enrollment : 67 participants
Observational Model: Case-Control
Time Perspective: Prospective
Official Title: Carpal Tunnel Syndrome in Patients With Psoriatic Arthritis; Ultrasonography and Magnetic Resonance Imaging Findings
Actual Study Start Date : March 15, 2019
Actual Primary Completion Date : March 15, 2020
Actual Study Completion Date : March 15, 2020


Group/Cohort Intervention/treatment
Psoriatic arthritis patients Diagnostic Test: Ultrasonography, Magnetic resonance imaging
The cross-sectional area of the median nerve was measured with US and MRI.

healthy volunteers Diagnostic Test: Ultrasonography, Magnetic resonance imaging
The cross-sectional area of the median nerve was measured with US and MRI.




Primary Outcome Measures :
  1. The cross-sectional area of the median nerve measured by US and MRI [ Time Frame: 12 months ]
    The measurement will be made at the pisiform bone level and with the continuous trace method.



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Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
PsA patients according to the CASPAR criteria who consecutively applied to the FTR outpatient clinic for PsA follow-up and healthy volunteers who applied to the FTR outpatient clinic enrolled in the study.
Criteria

Inclusion Criteria:

  • PsA patients according to the CASPAR criteria who consecutively applied to the FTR outpatient clinic for PsA follow-up and healthy volunteers who applied to the FTR outpatient clinic enrolled in the study.

Exclusion Criteria:

  • Patients were excluded from the study if they had history of conditions associated with an increased incidence of CTS except PsA (diabetes mellitus, pregnancy, hypothyroidism, renal failure or other severe systemic diseases); history or clinical/electrophyscologic finding of radiculopathy, plexopathy, polyneuropathy or any nervous system diseases; history of fractures, severe trauma or surgical interventions involving the wrist; bifid median nerve on wrist imaging and under the age of 18, over the age of 65. There was no history of rheumatic disease in the healthy volunteer group.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT05086042


Locations
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Turkey
Selcuk University Faculty of Medicine
Konya, Turkey
Sponsors and Collaborators
Selcuk University
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Responsible Party: Ezgi AKYILDIZ TEZCAN, M.D., Selcuk University
ClinicalTrials.gov Identifier: NCT05086042    
Other Study ID Numbers: CTSINPSAUSMRI
First Posted: October 20, 2021    Key Record Dates
Last Update Posted: October 20, 2021
Last Verified: October 2021

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Ezgi AKYILDIZ TEZCAN, Selcuk University:
Carpal Tunnel Syndrome
Psoriatic Arthritis
Ultrasonography
magnetic resonance imaging
Additional relevant MeSH terms:
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Arthritis
Arthritis, Psoriatic
Carpal Tunnel Syndrome
Syndrome
Disease
Pathologic Processes
Joint Diseases
Musculoskeletal Diseases
Spondylarthropathies
Spondylarthritis
Spondylitis
Spinal Diseases
Bone Diseases
Psoriasis
Skin Diseases, Papulosquamous
Skin Diseases
Median Neuropathy
Mononeuropathies
Peripheral Nervous System Diseases
Neuromuscular Diseases
Nervous System Diseases
Nerve Compression Syndromes
Cumulative Trauma Disorders
Sprains and Strains
Wounds and Injuries