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Basic Research Projects Related to Sports Injuries

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ClinicalTrials.gov Identifier: NCT04958551
Recruitment Status : Not yet recruiting
First Posted : July 12, 2021
Last Update Posted : March 15, 2022
Sponsor:
Information provided by (Responsible Party):
Peking University Third Hospital

Brief Summary:
Biological samples are important human genetic resources, which can provide great value for medical research, and how to protect and rationally utilize them is of great importance.However, at present, the blood samples after laboratory examination and the damaged tissue cleaned up in the operation will be treated as medical waste and treated according to the standard of medical waste.However, if these samples can be effectively collected and reasonably used, they can provide extremely high value for the study of sports injury-related diseases.Sports injury and joint structure belongs to multiple factors cause abnormal, through the degenerative osteoarthritis, cruciate ligament injury, patellar dislocation, discoid meniscus injury related basic research project establishment and collect the founding the research institute of sports medicine treated patients with sports injury, including degenerative osteoarthritis, intraoperative tissue, blood and saliva samples,To sample from the micro level of susceptibility genes and molecular signaling pathways to anatomical morphology and histopathologic study direction, and so on, can also for multiple transverse comparison research between samples, in order to investigate sports injury, including degenerative osteoarthritis pathogenesis, for sports trauma related disease etiology, diagnosis, treatment to provide new ideas and methods,And the selection of athletes, athletes special training plans, sports mode to provide more targeted suggestions.This study strictly complied with the Regulations of the People's Republic of China on the Management of Human Genetic Resources to establish the Institute of Sports Medicine Sample Bank, which can reduce the waste of human genetic resources in China, promote the development of the discipline, and provide a higher platform for the study of sports injure-related diseases.

Condition or disease Intervention/treatment
Osteoarthritis, Knee Cruciate Ligament Injury Patella Dislocation Discoid Meniscus of Knee Other: No intervention

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Study Type : Observational
Estimated Enrollment : 1000 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Basic Research Projects Related to Sports Injuries Such as Degenerative Osteoarthritis, Cruciate Ligament Injury, Patella Dislocation, Discoid Meniscus
Estimated Study Start Date : March 2022
Estimated Primary Completion Date : July 2024
Estimated Study Completion Date : July 2024

Resource links provided by the National Library of Medicine



Intervention Details:
  • Other: No intervention
    No intervention


Primary Outcome Measures :
  1. DNA-seq [ Time Frame: up to 2 weeks ]
    Whole genome sequencing


Biospecimen Retention:   Samples With DNA
Blood, tissue


Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Outpatients, inpatients, follow-up patients and third-class blood relatives or close relatives of patients with degenerative osteoarthritis, cruciate ligament injury, patella dislocation, discoid meniscus who were admitted to the Institute of Sports Medicine of the Third Hospital of Peking University, the Second Affiliated Hospital of Xinjiang Medical University,and Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine voluntarily enrolled in the biobase.
Criteria

Inclusion criteria:

  1. Outpatients, inpatients, follow-up patients and third-class blood relatives or close relatives of patients with degenerative osteoarthritis who were admitted to the Institute of Sports Medicine of the Third Hospital of Peking University, the Second Affiliated Hospital of Xinjiang Medical University,and Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine voluntarily enrolled in the biobase.
  2. Outpatients, inpatients, follow-up patients and third-class blood relatives or close relatives of patients with cruciate ligament injury who were admitted to the Institute of Sports Medicine of the Third Hospital of Peking University voluntarily enrolled in the biobase.
  3. Outpatients, inpatients, follow-up patients and third-class blood relatives or close relatives of patients with patella dislocation who were admitted to the Institute of Sports Medicine of the Third Hospital of Peking University voluntarily enrolled in the biobase.
  4. Outpatients, inpatients, follow-up patients and third-class blood relatives or close relatives of patients with discoid meniscus who were admitted to the Institute of Sports Medicine of the Third Hospital of Peking University voluntarily enrolled in the biobase.

Exclusion criteria: -.


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04958551


Contacts
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Contact: Jia-kuo Yu, Phd. +86 13331031448 yujiakuo@126.com

Sponsors and Collaborators
Peking University Third Hospital
Investigators
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Study Chair: Jia-kuo Yu, Phd. Institute of Sports Medicine, Peking University Third Hospital, Beijing, China, 100191
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Responsible Party: Peking University Third Hospital
ClinicalTrials.gov Identifier: NCT04958551    
Other Study ID Numbers: IRB00006761-M2021180
First Posted: July 12, 2021    Key Record Dates
Last Update Posted: March 15, 2022
Last Verified: June 2021
Additional relevant MeSH terms:
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Osteoarthritis
Osteoarthritis, Knee
Joint Dislocations
Patellar Dislocation
Wounds and Injuries
Athletic Injuries
Arthritis
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases
Knee Injuries
Leg Injuries