[18F] FDOPA PET Imaging in Glioma: Feasibility Study for PET Guided Brain Biopsy (FIG)
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|ClinicalTrials.gov Identifier: NCT04870580|
Recruitment Status : Recruiting
First Posted : May 3, 2021
Last Update Posted : July 29, 2022
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|Condition or disease||Intervention/treatment||Phase|
|Glioma||Diagnostic Test: Fluorodopa PET tracer||Not Applicable|
Glioma is a cancer of unmet need, where survival trends have not significantly changed for decades. The distinction between high-grade (HGG) and low-grade glioma (LGG) is important as both entities confer different prognoses and management strategies. This distinction is normally made on biopsy sampling and conventional imaging. However, sampling errors are not uncommon due to the heterogeneous nature of glioma. Case series have described under-grading of gliomas on biopsy in 28% to 63% of cases. Furthermore, up to one third of high-grade gliomas may not display the typical imaging characteristics (enhancement) of a high-grade glioma. Therefore, more accurate imaging may help to make this distinction and guide biopsy and clinical management decisions at the outset.
There has been growing interest in the use of amino acid PET in glioma imaging. Transport of amino acids across the blood brain barrier and low physiological levels of tracer uptake within the brain allow for good tumour visualisation. The most frequently used amino acid PET tracers described in clinical literature are [11C]methionine, [18F]fluoroethyltyrosine and [18F]fluorodopa, which predominantly reflect leucine transport, being mainly transported by LAT1, a high affinity leucine transporter. Alongside depiction of tumour volume, described roles of amino acid PET include differentiation of true disease progression from pseudo progression, detection of residual disease in the post-surgical patient, biopsy guidance and prognostication.
Rationale The primary objective of the study will be to establish the feasibility of performing [18F]fluorodopa PET guided histopathology in a single and multi-site setting. Basic tumour characterisation (for example Ki67 expression and detection of IDH mutations) will be undertaken.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||21 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||[18F] FDOPA PET Imaging in Glioma: Feasibility Study for PET Guided Brain Biopsy|
|Actual Study Start Date :||September 1, 2021|
|Estimated Primary Completion Date :||May 1, 2023|
|Estimated Study Completion Date :||May 1, 2023|
PET/CT with fluorodopa tracer
Diagnostic Test: Fluorodopa PET tracer
PET/CT scan using fluorodopa tracer
- To assess the feasibility of PET guided histopathology in a single and multi-site setting. [ Time Frame: 2 years ]Assessment of tumour standardised uptake values (SUV) from [18F]fluorodopa PET with matched histopathology data from biopsies for evaluable patients from a single site and multiple sites. The percentage of cases where it is possible to collect this data will inform the feasibility of performing the assessments in a single-site and multi-site setting with a 70% threshold used to determine feasibility.
- To investigate the inter-observer variation (IOV) in tumour to background uptake measurements to assess reliability. [ Time Frame: 2 years ]IOV in tumour to background uptake measurements
- To characterise dopamine uptake in high-grade glioma and low-grade glioma. [ Time Frame: 2 years ]SUV/TBR corresponding to the optimal cut-off value for high-grade and low-grade glioma on receiver operating characteristic curve analysis.
- To provide data on the proportion of high-grade transformation in low-grade glioma. [ Time Frame: 2 years ]Proportion of patients showing high-grade transformation following histopathology.
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|Ages Eligible for Study:||18 Years and older (Adult, Older Adult)|
|Sexes Eligible for Study:||All|
|Accepts Healthy Volunteers:||No|
- Age over 18 years
- Diagnosed with low-grade glioma based on clinical standard of care imaging and scheduled for primary surgical resection of low-grade glioma
- Females of childbearing potential and males agree to use an effective method of contraception from the time consent is signed until 1 week after surgery.
- Females of childbearing potential have a negative urine pregnancy test within 7 days prior to being registered. Participants are considered not of child bearing potential if they are surgically sterile (i.e. they have undergone a hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or they are postmenopausal
- Willing and able to provide written informed consent
- Females who are pregnant, planning pregnancy or breastfeeding
- Concurrent and/or recent involvement in other research or use of another experimental investigational medicinal product that is likely to interfere with the study medication within 28 days of study enrolment.
- MRI contraindicated (e.g. implanted electric and electronic devices, heart pacemakers, insulin pumps, implanted hearing aids, neurostimulators, intracranial metal clips, metallic bodies in the eye).
- Other psychological, social or medical condition, physical examination finding or a laboratory abnormality that the Investigator considers would make the patient a poor study candidate or could interfere with protocol compliance or the interpretation of study results.
- Neoadjuvant chemotherapy/radiotherapy treatment for low-grade glioma which would interfere with the interpretation of study results.
- Any other problems that may make the patient unable to tolerate the PET scans (e.g. claustrophobia).
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04870580
|Contact: JOY ROACH||01865 firstname.lastname@example.org|
|Contact: NCITA CTUemail@example.com|
|Oxford University Hospitals NHS Foundation Trust||Recruiting|
|Oxford, Oxfordshire, United Kingdom, OX3 9DU|
|Contact: Joy Roach, Dr 01865 270000 firstname.lastname@example.org|
|Contact: Edith Gallagher email@example.com|
|Principal Investigator:||Geoffrey Higgins||University College, London|
|Responsible Party:||University College, London|
|Other Study ID Numbers:||
272494 ( Other Identifier: IRAS )
|First Posted:||May 3, 2021 Key Record Dates|
|Last Update Posted:||July 29, 2022|
|Last Verified:||July 2022|
|Individual Participant Data (IPD) Sharing Statement:|
|Plan to Share IPD:||No|
|Studies a U.S. FDA-regulated Drug Product:||No|
|Studies a U.S. FDA-regulated Device Product:||No|
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