Working…
ClinicalTrials.gov
ClinicalTrials.gov Menu

The Relationship Between the Neural Drive and Intrinsic Positive End-expiratory Pressure

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT04840628
Recruitment Status : Recruiting
First Posted : April 12, 2021
Last Update Posted : May 6, 2021
Sponsor:
Information provided by (Responsible Party):
Zhang Jianheng, The First Affiliated Hospital of Guangzhou Medical University

Brief Summary:
To investigate the relation the nreural drive and intrinsic positive end-expiratory pressure(PEEPi) of the chronic obstructive pulmonary disease(COPD) patients with respiratory failure.In present study the PEEPi of COPD patients was increased by increasing the resistance of the respiratory system, the change of the neural drive was recorded.

Condition or disease Intervention/treatment Phase
Chronic Obstructive Pulmonary Disease Other: Resistance of the respiratory system Not Applicable

Detailed Description:
To investigate the relation the nreural drive and intrinsic positive end-expiratory pressure(PEEPi) of the chronic obstructive pulmonary disease(COPD) patients with respiratory failure.The diaphragm electromyogram (EMGdi) represents the neural drive to the diaphragm.A multi-pair esophageal electrode catheter was used to record the EMGdi.The PEEPi was assessed by the by the balloon-catheter in the multi-pair esophageal electrode catheter. In present study the PEEPi of COPD patients was increased by increasing the resistance of the respiratory system, the change of the neural drive( EMGdi) was obtained from the a multi-pair esophageal electrode catheter All the signal recorded in the computer. The relation the nreural drive assessed by EMGdi and intrinsic positive end-expiratory pressure(PEEPi) would be analysed.

Layout table for study information
Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 10 participants
Allocation: N/A
Intervention Model: Single Group Assignment
Intervention Model Description: the chronic obstructive pulmonary disease patients with respiratory failure
Masking: None (Open Label)
Primary Purpose: Other
Official Title: The Relationship Between the Nreural Drive and Intrinsic Positive End-expiratory Pressure of the Chronic Obstructive Pulmonary Disease Patients With Respiratory Failure
Actual Study Start Date : November 20, 2020
Estimated Primary Completion Date : June 21, 2021
Estimated Study Completion Date : July 3, 2021

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: neural respiratory drive
neural respiratory drive assessed by EMGdi recorded from a multipair esophageal electrode
Other: Resistance of the respiratory system
increase the resistance of the respiratory system of the chronic obstructive pulmonary disease patients




Primary Outcome Measures :
  1. neural respiratory drive assessed by the root mean square of diaphragm electromyogram (EMGdi) of the chronic obstructive pulmonary disease patients with respiratory failure [ Time Frame: 1 hour ]
    neural respiratory drive assessed by the root mean square of diaphragm electromyogram (EMGdi) obtained from the a multi-pair esophageal electrode catheter



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Layout table for eligibility information
Ages Eligible for Study:   50 Years to 70 Years   (Adult, Older Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

chronic obstructive pulmonary disease patients with respiratory failure

Exclusion Criteria:

  1. Heart failure
  2. cardiac dysrhythmia
  3. Loss of consciousness

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04840628


Contacts
Layout table for location contacts
Contact: jianheng zhang 86-13480226298 zhangjianhengjoy@aliyun.com

Locations
Layout table for location information
China, Guangdong
1State Key Laboratory of Respiratory Disease, National clinical research center for respiratory disease, Guangzhou Institute of respiratory health. 2The First Affiliated Hospital of Guangzhou Medical University Recruiting
Guangzhou, Guangdong, China, 520120
Contact: jianheng zhang, MD    13480226298    zhangjianhengjoy@aliyun.com   
Sponsors and Collaborators
The First Affiliated Hospital of Guangzhou Medical University
Layout table for additonal information
Responsible Party: Zhang Jianheng, Clinical Professor, The First Affiliated Hospital of Guangzhou Medical University
ClinicalTrials.gov Identifier: NCT04840628    
Other Study ID Numbers: YLS2020(142)
First Posted: April 12, 2021    Key Record Dates
Last Update Posted: May 6, 2021
Last Verified: May 2021
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Plan Description: we will share our data by publishing the paper

Layout table for additional information
Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Zhang Jianheng, The First Affiliated Hospital of Guangzhou Medical University:
neural respiratory drive
Intrinsic Positive End-expiratory Pressure
Chronic Obstructive Pulmonary Disease Patients
Additional relevant MeSH terms:
Layout table for MeSH terms
Lung Diseases
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Respiratory Tract Diseases
Respiratory System Agents