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Healthcare-associated Infections in Severe COVID-19 During 2020 (COVIACS)

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ClinicalTrials.gov Identifier: NCT04819165
Recruitment Status : Completed
First Posted : March 26, 2021
Last Update Posted : March 26, 2021
Sponsor:
Information provided by (Responsible Party):
Matias Accoce, Sanatorio Anchorena San Martin

Brief Summary:
In patients who develop ARDS due to SARS-CoV-2 (CARDS), a longer duration of invasive mechanical ventilation (IMV) and ICU stay has been reported compared to ARDS not associated with SARS-CoV-2. Consequently, the days of stay in ICU increase Identifying the risk factors associated with the development of this complication and developing measures aimed at its prevention could have a favorable impact on the clinical course of seriously ill patients.

Condition or disease Intervention/treatment
Respiration, Artificial COVID-19 Health Care Associated Infection Other: COVID-19

Detailed Description:

The rate of catheter-associated bacteremia is 3.78 / 1000 days central venous catheters in polyvalent ICUs.

Some studies suggest that in the context of this pandemic, infections associated with health care have increased, although there are few data referring to Latin America.

The objective of this study is to analyze the incidence of health care associated infections in adult patients on invasive mechanical ventilation with confirmed COVID-19 diagnosis and negative COVID-19 admitted to the Intensive Care Unit of the Anchorena San Martín Clinic, San Martín, Buenos Aires.

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Study Type : Observational
Actual Enrollment : 252 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Healthcare-associated Infections in Severe COVID-19 Patients Whit Mechanical Ventilation During 2020
Actual Study Start Date : March 1, 2020
Actual Primary Completion Date : December 31, 2020
Actual Study Completion Date : January 31, 2021

Resource links provided by the National Library of Medicine


Group/Cohort Intervention/treatment
COVID-19 patients
Patients with invasive mechanical ventilation admitted to the Intensive Care Unit (UCI) of the Anchorena San Martín Clinic, San Martín, Buenos Aires with confirmed COVID-19 diagnosis (positive polymerase chain reaction in nasopharyngeal swab).
Other: COVID-19
Impact of covid-19 on infections associated with health care devices.

non COVID-19 patients
Patients with invasive mechanical ventilation admitted to the Intensive Care Unit (UCI) of the Anchorena San Martín Clinic, San Martín, Buenos Aires with negative COVID-19 diagnosis (positive polymerase chain reaction in nasopharyngeal swab).



Primary Outcome Measures :
  1. Incidence of health care associated infections in each group. [ Time Frame: March to December 2020 ]

Secondary Outcome Measures :
  1. The most frequent pathogens in this population associated with Incidence of health care associated infections. [ Time Frame: March to December 2020 ]
  2. Possible factors associated with Incidence of health care associated infections. [ Time Frame: March to December 2020 ]
  3. mortality in UCI [ Time Frame: March to December 2020 ]
  4. Days of ICU stay [ Time Frame: March to December 2020 ]
  5. Days of mechanical ventilation [ Time Frame: March to December 2020 ]


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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients admitted to ICU who required invasive mechanical ventilation during the COVID-19 pandemic from March to December 2020.
Criteria

Inclusion Criteria:

  • All patients older than 18 years admitted to the intensive care unit of the Anchorena San Martín Clinic who required invasive mechanical ventilation for more than 24 hours in a period between March 2020 and December 2020 were included in the analysis.

Exclusion Criteria:

  • All patients who presented incomplete data in the follow-up sheets were excluded.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04819165


Locations
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Argentina
Sanatorio Anchorena de San Martin
San Martín, Buenos Aires, Argentina, B1650CQU
Sponsors and Collaborators
Sanatorio Anchorena San Martin
Investigators
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Principal Investigator: matias accoce SAnchorena San Martin
Publications of Results:

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Responsible Party: Matias Accoce, RT, Sanatorio Anchorena San Martin
ClinicalTrials.gov Identifier: NCT04819165    
Other Study ID Numbers: 5/2021
First Posted: March 26, 2021    Key Record Dates
Last Update Posted: March 26, 2021
Last Verified: March 2021
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Infections
Communicable Diseases
COVID-19
Cross Infection
Disease Attributes
Pathologic Processes
Respiratory Tract Infections
Pneumonia, Viral
Pneumonia
Virus Diseases
Coronavirus Infections
Coronaviridae Infections
Nidovirales Infections
RNA Virus Infections
Lung Diseases
Respiratory Tract Diseases
Iatrogenic Disease