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A Study to Evaluate CBP-201 in Adult Patients With Chronic Rhinosinusitis With Nasal Polyps

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT04783389
Recruitment Status : Terminated (Trial was discontinued in 2022 due to COVID-19 pandemic and Ukraine/Russia conflict related enrollment challenges. Discontinuation was not related to safety.)
First Posted : March 5, 2021
Last Update Posted : July 5, 2022
Sponsor:
Information provided by (Responsible Party):
Suzhou Connect Biopharmaceuticals, Ltd.

Brief Summary:
This study will evaluate the effect of CBP-201 in adult patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP).

Condition or disease Intervention/treatment Phase
Chronic Rhinosinusitis With Nasal Polyps Drug: CBP-201 Drug: Placebo Phase 2

Detailed Description:
This is a multicenter, randomized, double-blind, placebo-controlled study to evaluate the effect of CBP-201 on a background of mometasone furoate nasal spray (MFNS) in reducing endoscopic nasal polyp score (NPS) and nasal congestion/obstruction score (NCS) severity in eligible patients with CRSwNP whose disease remains inadequately controlled despite daily treatment with intranasal corticosteroid (INCS) therapy in comparison to placebo. CBP-201 is administered as a subcutaneous (SC) injection. The study is divided into a treatment period of 24 weeks and a follow-up period of 8 weeks.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 40 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: A Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate CBP-201 in Adult Patients With Chronic Rhinosinusitis With Nasal Polyps
Actual Study Start Date : June 16, 2021
Actual Primary Completion Date : April 15, 2022
Actual Study Completion Date : June 10, 2022

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: CBP-201 Dose 1
CBP-201 Dose 1 subcutaneous (SC) injection.
Drug: CBP-201
CBP-201 subcutaneous (SC) injection.

Experimental: CBP-201 Dose 2
CBP-201 Dose 2 subcutaneous (SC) injection.
Drug: CBP-201
CBP-201 subcutaneous (SC) injection.

Placebo Comparator: Placebo
Placebo subcutaneous (SC) injection.
Drug: Placebo
Placebo subcutaneous (SC) injection.




Primary Outcome Measures :
  1. Change in endoscopic nasal polyp score (NPS) [ Time Frame: From Baseline at Week 24 ]
    Change from baseline at Week 24 in endoscopic nasal polyp score (NPS). Endoscopic NPS is graded based on polyp size (recorded as the sum of the right and left nostril scores with a range of 0 to 8; higher scores indicate worse status).

  2. Change in average daily nasal congestion score (NCS) [ Time Frame: From Baseline at Week 24 ]
    Change from baseline at Week 24 in average daily nasal congestion score (NCS).


Secondary Outcome Measures :
  1. Change in percentage of maxillary sinus volume occupied by disease [ Time Frame: From Baseline at Week 24 ]
    Change from baseline at Week 24 in percentage of maxillary sinus volume occupied by disease on CT and Lund-Mackay Computed Tomography scores.

  2. Change in University of Pennsylvania Smell Identification Test (UPSIT) [ Time Frame: From Baseline at Week 24 ]
    Change from baseline at Week 24 in University of Pennsylvania Smell Identification Test (UPSIT).

  3. Change in visual analogue scale for rhinosinusitis (VAS-RS) [ Time Frame: From Baseline to Week 24 ]
    Change from baseline at Week 24 in Visual analogue scale for rhinosinusitis (VAS-RS).

  4. Change in total nasal symptom score (TNSS) [ Time Frame: From Baseline to Week 24 ]
    Change from baseline at Week 24 in total nasal symptom score (TNSS).

  5. Change in 22-item Sinonasal Outcome Test (SNOT-22) [ Time Frame: From Baseline to Week 24 ]
    Change from baseline at Week 24 in 22-item Sinonasal Outcome Test (SNOT-22)

  6. Change in average daily anterior rhinorrhea score [ Time Frame: From Baseline to Week 24 ]
    Change from baseline at Week 24 in average daily anterior rhinorrhea score

  7. Change in average daily posterior rhinorrhea score [ Time Frame: From Baseline to Week 24 ]
    Change from baseline at Week 24 in average daily posterior rhinorrhea score.

  8. Change in average daily loss of smell score [ Time Frame: From Baseline to Week 24 ]
    Change from baseline at Week 24 in average daily loss of smell score

  9. Change in daily subject-assessed nasal peak inspiratory flow (NPIF) [ Time Frame: From Baseline to Week 24 ]
    Change from baseline at Week 24 in daily subject-assessed nasal peak inspiratory flow (NPIF).

  10. Incidence, type and severity of Adverse Event (AE) [ Time Frame: From Baseline to Week 32 ]
    Safety endpoints will be summarized by descriptive statistics and narratives where indicated by severity. Safety will be assessed on basis of AEs reported, including SAEs and AESIs.

  11. Area under plasma concentration-time curve from baseline to the last point with measurable analyte concentration (AUC0-t) [ Time Frame: From Baseline to Week 32 ]
    Area under plasma concentration-time curve from baseline to the last point with measurable analyte concentration (AUC0-t) will be analyzed as a pharmacokinetic (PK) parameter.

  12. Area under plasma concentration-time curve from baseline to extrapolated to infinite time (AUC0-inf) [ Time Frame: From Baseline to Week 32 ]
    Area under plasma concentration-time curve from baseline to extrapolated to infinite time (AUC0-inf ) will be analyzed as a pharmacokinetic (PK) parameter.

  13. Maximal plasma concentration (Cmax) [ Time Frame: From Baseline to Week 32 ]
    Maximal plasma concentration (Cmax) will be analyzed as a pharmacokinetic (PK) parameter.

  14. Time to maximal concentration (tmax) [ Time Frame: From Baseline to Week 32 ]
    Time to maximal concentration (tmax) will be analyzed as a pharmacokinetic (PK) parameter.

  15. Change from Baseline in blood level of IgE [ Time Frame: From Baseline to Week 32 ]
    Change from baseline will be summarized with descriptive statistics in blood level of IgE.

  16. Change from Baseline in peripheral eosinophil counts [ Time Frame: From Baseline to Week 32 ]
    Change from baseline will be summarized with descriptive statistics in peripheral eosinophil counts.

  17. Change from Baseline in eosinophil cationic protein (ECP) [ Time Frame: From Baseline to Week 32 ]
    Change from baseline will be summarized with descriptive statistics in eosinophil cationic protein (ECP).

  18. Change from Baseline in thymus and activation-regulated chemokine (TARC) [ Time Frame: From Baseline to Week 32 ]
    Change from baseline will be summarized with descriptive statistics in thymus and activation-regulated chemokine (TARC).

  19. Change from Baseline in Eotaxin-3 [ Time Frame: From Baseline to Week 32 ]
    Change from baseline will be summarized with descriptive statistics in Eotaxin-3.

  20. Change from Baseline in periostin [ Time Frame: From Baseline to Week 32 ]
    Change from baseline will be summarized with descriptive statistics in periostin.

  21. Requirement of rescue treatment (systemic CS for > 5 consecutive days) or having had surgery for nasal polyps [ Time Frame: Through Week 24 ]
    Requirement of rescue treatment (systemic CS for > 5 consecutive days) or having had surgery for nasal polyps through Week 24

  22. Time to rescue treatment (systemic CS for > 5 consecutive days) or surgery for nasal polyps [ Time Frame: Through Week 24 ]
    Time to rescue treatment (systemic CS for > 5 consecutive days) or surgery for nasal polyps through Week 24.



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  1. Female and male patients aged ≥ 18 and ≤ 75 years at the time of screening.
  2. Patients who are diagnosed with chronic rhinosinusitis with bilateral polyps despite treatment with systemic corticosteroid within the past 2 years and/or medical contraindication/intolerance to systemic corticosteroids. The polyps have a minimum bilateral NPS of 5 out of a maximum score of 8 with at least a score of 2 for each nostril at screening and baseline evaluated by endoscopy.
  3. Nasal congestion/blockade/obstruction with moderate or severe symptom severity (Nasal Congestion Score of > 2) at screening and a weekly average severity of > 1 at time of randomization.
  4. Patients using a documented stable dose of nasal mometasone at least 200 mcg/day, or an equivalent daily dose of another INCS, for at least 28 days before randomization and willing to continue the dose for the duration of the study. Note: For patients who are using an alternative INCS product other than mometasone furoate nasal spray (MFNS) prior to the screening visit, the investigator must switch the patient to MFNS at V1.
  5. Patients willing to enter Patient Diary daily symptom assessments and maintain stable dosing with MFNS with a compliance of at least 70% in the 7 days preceding randomization. Note: Patients must use nasal mometasone at least 200 mcg/day, or equivalent, for at least 28 days before randomization, which can include days prior to screening with supportive documentation. Run-in can be 7-31 days with the compliance determined in the week prior to dosing.
  6. Male patients who are non-sterilized and sexually active with a female partner of childbearing potential agree to use highly effective contraception from randomization until 8 weeks after last dose.
  7. Female patients of childbearing potential who are sexually active with a nonsterilized male partner should have a confirmed negative serum beta-human chorionic gonadotropin test at Visit 1 and agrees to use highly effective contraception from signing of informed consent throughout the duration of the study and for 8 weeks after last dose.
  8. Patient is able to understand and willing to sign the informed consent form (ICF) prior to any study related procedures being performed.
  9. Willing and able to comply with all study visits and study-related procedures, in the opinion of the Investigator.

    Exclusion Criteria:

    -

    A patient who meets any of the following criteria will be ineligible to participate in this study:

  10. Patients unable to use MFNS.
  11. Patients who are taking or have taken the following prohibited therapies as specified:

    1. Systemic steroids within 28 days prior to screening,
    2. Other nonbiologic investigational drugs within 60 days (or 5 half-lives, whichever is longer) of screening,
    3. Intranasal corticosteroid drops or corticosteroid-administering devices (eg, OptiNose device or stents) within 28 days prior to screening,
    4. Non-steroidal immunosuppressants (eg, cyclosporine, methotrexate, azathioprine, mycophenolate, sirolimus, tacrolimus) within 60 days or 5 half-lives, whichever is longer, of screening,
    5. Any monoclonal antibody therapy (eg, benralizumab, mepolizumab, omalizumab, resilizumab, dupilumab) or investigational biologic drug for asthma or other diseases within 60 days or 5 half-lives, whichever is longer, of screening,
    6. Leukotriene antagonists/modifiers within 7 days prior to screening for patients who were not on continuous treatment for ≥ 30 days prior to screening,
    7. Allergen immunotherapy for patients who were not on maintenance treatment for at least 90 days prior to screening
  12. Patients who did not respond favorably to previous dupilumab treatment (eg, therapy failure or patient experienced an adverse reaction to treatment).
  13. Patients who have undergone any nasal surgery (including polypectomy) within 6 months before screening; or have a history of sinus or nasal surgery modifying the structure of the nose such that assessment of NPS is not possible, or have had uncontrolled epistaxis requiring surgical or procedural intervention, including nasal packing.
  14. Patients with conditions/concomitant diseases making them non evaluable at screening or for the primary efficacy endpoint such as: antrochoanal polyps, nasal septal deviation that would occlude at least 1 nostril, acute sinusitis, nasal infection or upper respiratory infection at screening or within 2 weeks before screening, ongoing rhinitis medicamentosa; known or suspected diagnosis of cystic fibrosis; chronic granulomatous disease and granulomatous vasculitis, granulomatosis with polyangiitis (Wegener's Granulomatosis), eosinophilic granulomatous with polyangiitis (Churg-Strauss syndrome), Young's syndrome, primary dyskinetic ciliary syndromes (eg, Kartagener's syndrome) or other dyskinetic ciliary syndromes.
  15. Signs or a CT scan suggestive of Allergic Fungal Rhinosinusitis.
  16. Patients with co-morbid asthma are excluded if:

    1. Forced Expiratory Volume in 1 second (FEV1) ≤ 50% of normal predicted value OR
    2. An exacerbation within 90 days prior screening that required hospitalization (> 24 hours) OR
    3. Are on a daily dose of inhaled corticosteroids (ICS) higher than 1000 mcg fluticasone or the equivalent.
  17. Known or suspected history of immunosuppression, including history of invasive opportunistic infections, such as aspergillosis, coccidioidomycosis, histoplasmosis, human immunodeficiency virus (HIV), listeriosis, pneumocystosis, or tuberculosis, despite infection resolution; or unusually frequent, recurrent or prolonged infections. Tuberculosis testing would be performed on a country-by-country basis according to local guidelines if required by regulatory authorities or ethics committees.
  18. Patients who have active Hepatitis B, Hepatitis C or HIV infections as determined by positive results at Screening for hepatitis B surface antigen (HBsAg) or hepatitis B core antibody (HBcAb); or hepatitis C (HCV) antibody; or positive HIV serology. Note: Patients who test positive for HBvAb, negative for HBsAg and subsequently confirmed positive for HBsAb, indicating resolved natural infection (confirmed by negative HBV-DNA), may participate. Patients with positive HCV may participate if subsequent viral load is confirmed negative.
  19. A helminth parasitic infection diagnosed within 24 weeks prior to the date of informed consent that has not been treated, or has failed to respond to, standard of care therapy.
  20. Evidence of infection requiring treatment with systemic antibacterials, antivirals, antifungals, antiparasitics, or antiprotozoals within 7 days before baseline, or viral infections within 14 days before screening that may not have received antiviral treatment.
  21. Live, attenuated vaccinations within 28 days prior to screening or planned live, attenuated vaccinations during the study.
  22. Pregnant or intent to become pregnant during the study, or breast-feeding women.
  23. Any disorder, including, but not limited to, cardiovascular, gastrointestinal, hepatic, renal, neurological, musculoskeletal, infectious, endocrine, metabolic, haematological, psychiatric, or major physical impairment that is not stable in the opinion of the investigator and may affect the safety of the patient throughout the study, or influence the findings of the studies or their interpretations, or impede the patient's ability to complete the entire duration of study.
  24. Any clinically significant abnormal findings in physical examination, vital signs, safety lab tests during screening/run-in period, which in the opinion of the investigator, may put the patient at risk because of their participation in the study, or may influence the results of the study, or the patient's ability to complete entire duration of the study.
  25. Have any of the following laboratory abnormalities at Screening:

    1. Eosinophils >1500 cells/mm3 (or 1.5 x 10E9/L)
    2. Platelets <100000 cells/mm3 (or 100 x 10E9/L)
    3. Creatine phosphokinase (CPK) > 10 upper limit of normal (ULN)
    4. Alanine aminotransferase (ALT) > 2.5 times the ULN
    5. Aspartate aminotransferase (AST) ≥ 2.5 times the ULN
    6. Bilirubin ≥ 2 times the ULN
  26. History of alcohol or drug abuse within 12 months prior to the date informed consent.
  27. An allergy to L-histidine, trehalose or Tween (polysorbate) 80 or a history of a systemic hypersensitivity reaction, other than localized injection site reaction, to any biologic drug.
  28. Plans to undergo any surgical procedure requiring general anesthesia during the study.
  29. History of cancer: Patients who have had basal cell carcinoma, localized squamous cell carcinoma of the skin, or in situ carcinoma of the cervix are eligible provided that the patient is in remission and curative therapy was completed at least 12 months prior to the date informed consent. Note: Patients who have had other malignancies are eligible provided that the patient is in remission and curative therapy was completed at least 5 years prior to the date of informed consent.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04783389


Locations
Show Show 68 study locations
Sponsors and Collaborators
Suzhou Connect Biopharmaceuticals, Ltd.
Investigators
Layout table for investigator information
Study Director: Suzhou Connect Suzhou Connect Biopharmaceuticals, Ltd.
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Responsible Party: Suzhou Connect Biopharmaceuticals, Ltd.
ClinicalTrials.gov Identifier: NCT04783389    
Other Study ID Numbers: CBP-201-WW003
First Posted: March 5, 2021    Key Record Dates
Last Update Posted: July 5, 2022
Last Verified: June 2022
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: Yes
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Sinusitis
Nasal Polyps
Polyps
Pathological Conditions, Anatomical
Respiratory Tract Infections
Infections
Paranasal Sinus Diseases
Nose Diseases
Respiratory Tract Diseases
Otorhinolaryngologic Diseases