Respiratory Effects of Dopamine in the Perioperative Care (DOPHUMAN)
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|ClinicalTrials.gov Identifier: NCT04753008|
Recruitment Status : Active, not recruiting
First Posted : February 12, 2021
Last Update Posted : February 12, 2021
Dopamine is frequently used as an inotropic drug to elevate cardiac output. In addition to the beneficial cardiac effect of this drug, the few previous studies addressing its ability to alter the airway tone reported controversial results.
Thus, the investigators aimed at clarifying the potential of dopamine to alter gas exchange outcomes and the airway tone in patients undergoing cardiac surgeries with cardiopulmonary bypass.
Blood gas parameters, airway resistance, tissue damping and tissue elastance will be measured in the patients before the CPB, immediately after CPB, and 5 min after administration of dopamine (3 mcg/kg/min).
The importance of the research is to reveal whether the beneficial mechanical changes after dopamine administrations are associated with improvements in gas exchange outcomes. Clarification of this research question have scientific relevance and may also improves patient outcomes.
|Condition or disease||Intervention/treatment||Phase|
|Dopamine Bronchodilation Heart Surgery Functional Disturbance||Drug: Dopamine administration||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||100 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Double (Participant, Outcomes Assessor)|
|Official Title:||Respiratory Effects of Dopamine in the Perioperative Care|
|Actual Study Start Date :||December 13, 2010|
|Estimated Primary Completion Date :||March 31, 2021|
|Estimated Study Completion Date :||December 31, 2021|
Experimental: Dopamine group
Cardiac surgery patients receiving dopamine to support their cardiac function (as part of the routine post-operative care).
Drug: Dopamine administration
Administration of dopamine (3 mcg/kg/min) as part of cardiac support therapy after the cardiopulmonary bypass. Administration of dopamine is a subject of clinical decision based on the cardiovascular status of the patients.
No Intervention: Control group
Cardiac surgery patients receiving no positive inotrope drug.
- Arterial oxygen partial pressure (PaO2) [ Time Frame: 5 min after administration of dopamine ]Partial pressure of oxygen in the blood sample assessed by a blood gas analyser.
- Arterial carbon dioxide partial pressure (PaCO2) [ Time Frame: 5 min after administration of dopamine ]Partial pressure of carbon dioxide in the blood sample assessed by a blood gas analyser.
- Lung mechanics [ Time Frame: 5 min after administration of dopamine ]Airway resistance, lung tissue damping and lung tissue elastance obtained by forced oscillation technique.
- Capnography [ Time Frame: 5 min after administration of dopamine ]Time capnography to obtain phase 3 and phase 2 slopes.
- Intrapulmonary shunt [ Time Frame: 5 min after administration of dopamine ]Intrapulmonary shunt obtained by the Berggren shunt equation from arterial and central venous blood samples.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04753008
|Szeged, Hungary, 6725|