VR Motor-cognitive Training for Older People With Cognitive Frailty
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|ClinicalTrials.gov Identifier: NCT04730817|
Recruitment Status : Not yet recruiting
First Posted : January 29, 2021
Last Update Posted : January 29, 2021
Cognitive frailty is a clinical syndrome in which cognitive impairment (e.g., poor memory, visuospatial function) and physical frailty (e.g., slowness, poor muscle strength, physical inactivity) co-exist. It is prevalent in community-dwelling older people. The progressive decline of cognitive and physical functions restricts older people from participating in activities (e.g., social get-togethers). Reduced participation further jeopardizes their life-space mobility (e.g., ability to travel to areas far away from home). Therefore, those with cognitive frailty are at risk of developing dementia and becoming dependent.
Simultaneous motor-cognitive training is more effective at promoting optimal functioning in older people than motor or cognitive training alone. Gaming is effective at promoting the motivation to participate. The contents of games in the market are unrelated to the context or daily living of the elderly. Currently, available training is non-simultaneous. This makes the training less transferable to the daily life of the elderly and reduces its effects.
Virtual reality (VR) technology can provide a virtual space that mimics the real environment. This allows clients to participate in daily activities in a virtual space. Older people can be trained to improve their cognitive and physical skills in a painless, fun way. However, the effect and feasibility of employing simultaneous motor-cognitive training launching on a VR platform mimicking the daily living environment in older people with cognitive frailty is poorly known.
Following the findings from the previous proof-of-concept test (registration number: NCT04467216), we proceed to implement the study to 400 participants from six different elderly centres between the period of March 2021 and December 2022.
|Condition or disease||Intervention/treatment||Phase|
|Cognitive Frailty Physical Function||Device: Virtual Reality Motor-Cognitive Training System||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||400 participants|
|Intervention Model:||Parallel Assignment|
|Intervention Model Description:||
A total of 400 subjects with cognitive frailty will be assigned into 2 groups. Half the participants will be assigned to the intervention group in which they will undertake VR simultaneous motor-cognitive training and others will be assigned to the control group in the form of passive (wait list) control, i.e., they will not be given any kind of treatment.
The following dosage will be employed onto the intervention group using the VR simultaneous motor-cognitive training that we proposed. I.e.,
Course: eight weeks Session duration: 30 minutes Frequency: twice per week
|Masking:||Single (Outcomes Assessor)|
|Masking Description:||Outcome assessors at both pre- and post-observations will be blinded to the group label.|
|Official Title:||Virtual Reality Motor-cognitive Training for Older People With Cognitive Frailty: The Implementation of the Prototype|
|Estimated Study Start Date :||March 2021|
|Estimated Primary Completion Date :||May 2021|
|Estimated Study Completion Date :||December 2022|
Experimental: Intervention group
This arm will undertake VR simultaneous motor-cognitive training in 30 minutes session, twice a week for 8 weeks.
Device: Virtual Reality Motor-Cognitive Training System
Immersive VR training system tailor-made for the daily living experiences in the Hong Kong context to provide interactive experiences for older people in Hong Kong. The VR training system is designed as a game with 16 progressive levels (anticipating intervention group participants to complete 2 levels per week for 8 weeks) which aim to train their motor and cognitive functions.
No Intervention: Control group
This arm will not be given any kind of treatment and will act as a passive control group.
- Global cognitive function [ Time Frame: Change is being assessed at "baseline" (T0) and "immediately after the completion" (T1), being 8 weeks apart ]Score on the Montreal Cognitive Assessment Hong Kong Version (HK-MoCA), ranging from 0 to 30.
- Frailty [ Time Frame: Change is being assessed at "baseline" (T0) and "immediately after the completion" (T1), being 8 weeks apart ]Score on the Fried Frailty Phenotype, ranging from 0 to 5
- Inhibition of cognitive interference [ Time Frame: Change is being assessed at "baseline" (T0) and "immediately after the completion" (T1), being 8 weeks apart ]Stroop Color-Word Test (SCWT) Global Index score, calculated by I=CW-((W+C)/2)
- Executive function [ Time Frame: Change is being assessed at "baseline" (T0) and "immediately after the completion" (T1), being 8 weeks apart ]Time taken to complete the trail making test (TMA & TMB), ranges from 0 to 300 seconds (when maximum time is reached)
- Verbal and visuo-spatial short-term memory [ Time Frame: Change is being assessed at "baseline" (T0) and "immediately after the completion" (T1), being 8 weeks apart ]Score on the Digit Span Test, ranges from 0 to 9
- Walking speed [ Time Frame: Change is being assessed at "baseline" (T0) and "immediately after the completion" (T1), being 8 weeks apart ]Timed up and go test (seconds)
- Hand grip strength [ Time Frame: Change is being assessed at "baseline" (T0) and "immediately after the completion" (T1), being 8 weeks apart ]Hand grip strength by dynamometer (kg)
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04730817
|Contact: Rick Kwan, Dr||(852) 2766 ext email@example.com|
|Contact: Justina Liu, Dr||(852) 2766 ext firstname.lastname@example.org|
|Pok Oi Hospital Chan Shi Sau Memorial Social Service Centre|
|Hong Kong, Hong Kong|
|Contact: Thomas Tsang 29848018 email@example.com|
|Pok Oi Hospital Mei Foo Lai Wan Kaifong Association Mr. and Mrs. Leung Chi Chim Elderly Health Support and Learning Centre|
|Lai Chi Kok, Hong Kong|
|Contact: Kaman Chung 2310 4848 firstname.lastname@example.org|
|Pok Oi Hospital Mr. Kwok Hing Kwan Neighbourhood Elderly Centre|
|Lai Chi Kok, Hong Kong|
|Contact: Olive Sin 36146402 email@example.com|
|Pok Oi Hospital Chan Ping Memorial Neighbourhood Elderly Centre|
|Tin Shui Wai, Hong Kong|
|Contact: Mandy Wong 24781930 firstname.lastname@example.org|
|Pok Oi Hospital Wong Muk Fung Memorial Elderly Health Support and Learning Centre|
|Tuen Mun, Hong Kong|
|Contact: Shane WL Siauw 25650877 email@example.com|
|Pok Oi Hospital Mrs. Wong Tung Yuen District Elderly Community Centre|
|Yuen Long, Hong Kong|
|Contact: Lai Yung Tong 2476 2227 firstname.lastname@example.org|
|Principal Investigator:||Rick Kwan, Dr||The Hong Kong Polytechnic University|