Expanded Access Program (EAP) for Avapritinib in Patients With AdvSM
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This is a US, multicenter, open-label expanded access program designed to provide access to avapritinib in eligible patients with AdvSM until such time that avapritinib becomes available through other mechanisms, or the Sponsor chooses to discontinue the program.
Condition or disease
Advanced Systemic MastocytosisAggressive Systemic MastocytosisSystemic Mastocytosis With an Associated Hematological NeoplasmMast Cell Leukemia
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Layout table for eligibility information
Ages Eligible for Study:
12 Years and older (Child, Adult, Older Adult)
Sexes Eligible for Study:
Patients who are ≥ 15 years of age, or ≥ 12 years of age AND ≥ 35 kg.
Patients must have a diagnosis of advanced systemic mastocytosis (AdvSM) or smoldering systemic mastocytosis (SSM). AdvSM includes the following:
Aggressive systemic mastocytosis (ASM)
Systemic mastocytosis with an associated hematological neoplasm of non-mast-cell lineage (SM-AHN)
Mast cell leukemia (MCL)
Patient or legal guardian, if permitted by local regulatory authorities, provides written informed consent.
Patient is not eligible for an ongoing study of avapritinib or cannot access an ongoing study of avapritinib.
Patient meets any of the following laboratory criteria:
Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 3.0 × upper limit of normal (ULN); no restriction if due to suspected liver infiltration by mast cells.
Bilirubin > 1.5 × ULN (>3 x ULN in the case of Gilbert's disease); no restriction if due to suspected liver infiltration by mast cells or Gilbert's disease.
Platelet count < 50,000/μL (within 4 weeks of the first dose of avapritinib) or receiving platelet transfusion(s).
Patient has a history of a cerebrovascular accident or transient ischemic attacks within 1 year before the first dose of avapritinib or any other known risks of intracranial bleeding.
Patient has a known risk or recent history (12 months before the first dose of avapritinib) of intracranial bleeding (e.g., brain aneurysm, concomitant vitamin K antagonist use).
Patient has a primary brain malignancy or metastases to the brain.
Patient has clinically significant, uncontrolled cardiovascular disease, including Grade III or IV congestive heart failure according to the New York Heart Association classification; myocardial infarction or unstable angina within the previous 6 months; clinically significant, uncontrolled arrhythmias; or uncontrolled hypertension.
Female patients who are unwilling, if not postmenopausal or surgically sterile, to abstain from sexual intercourse or employ highly effective contraception during the avapritinib administration period and for at least 30 days after the last dose of avapritinib. Men who are unwilling, if not surgically sterile, to abstain from sexual intercourse or employ highly effective contraception during the avapritinib administration period and for at least 90 days after the last dose of avapritinib.
Women who are pregnant or breast feeding.
Patient has had a major surgical procedure (minor surgical procedures such as central venous catheter placement, tumor needle biopsy, and feeding tube placement are not considered major surgical procedures) within 14 days prior to the first dose of avapritinib.
Hypersensitivity to avapritinib or to any of the excipients.
Patient is participating in another interventional study.