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Predicting the Efficacy of Resistance Exercise Training for Improving Endurance Performance (IDperform)

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ClinicalTrials.gov Identifier: NCT04637178
Recruitment Status : Recruiting
First Posted : November 19, 2020
Last Update Posted : November 19, 2020
Sponsor:
Information provided by (Responsible Party):
Inland Norway University of Applied Sciences

Brief Summary:
The overall objective of the study is to identify molecular determinants of the efficacy of resistance training for improving endruance performance in elite cyclists

Condition or disease Intervention/treatment Phase
Elite Cyclists Behavioral: Resistance training Behavioral: Endurance training (habitual) Not Applicable

Detailed Description:

For elite endurance athletes, the addition of resistance training to habitual endurance training routines generally leads to improved endurance performance. However, this is not always the case, with several individuals failing to respond in the expected manner. This inter-individual variation is likely associated with inherent cellular and molecular charateristics of skeletal muscle. Indeed, responses to resistance training seem to be associated with muscle biological characteristics such as muscle fiber composition and ribosomal content (during the early phase of resistance training).

The study will investigate the association between muscle fibre composition (type I vs type II muscle fiber proportions) / ribosomal content in m. vastus lateralis and the effects of 10 weeks of resistance training on endurance performance in 52 elite cyclists. Half the participants will perform resistance training in addition to their habitual endurance training routines, the other half will perform endurance training-only. Muscle biopsies will be sampled from m. vastus lateralis before and after the first two weeks of the intervention. For muscle fiber composition, the hypothesis is that larger proportions of type II fibers will be associated with more pronounced benefits of resistance training. For ribosomal content, the hypothesis is that higher rRNA content at baseline and larger increases in rRNA content during the initial part of the intervention will be associated with more pronounced benefits of resistance training. No changes are expected in the non-resistance training control group.

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 52 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Masking Description: Participants/investigators will be blinded to muscle biological charateristics until after clean-up of main outcome variables. Participants/investigators will be aware of intervention arm affiliation.
Primary Purpose: Treatment
Official Title: Identifying Molecular Determinants for the Efficacy of Resistance Training for Improving Endurance Performance in Elite Cyclists
Estimated Study Start Date : November 16, 2020
Estimated Primary Completion Date : February 28, 2021
Estimated Study Completion Date : February 28, 2021

Arm Intervention/treatment
Experimental: Resistance training added to endurance training
Participants (elite cyclists) will conduct heavy-load resistance training twice a week in addition to their habitual endurance training for ten weeks
Behavioral: Resistance training
Resistance training sessions twice a week for ten weeks
Other Name: Heavy-load strength training

Behavioral: Endurance training (habitual)
Endurance training for ten weeks (habitual routines)

Endurance training
Participants (elite cyclists) will conduct habitual endurance training-only for ten weeks
Behavioral: Endurance training (habitual)
Endurance training for ten weeks (habitual routines)




Primary Outcome Measures :
  1. Performance during a 40-minute all-out cycling test [ Time Frame: Changes from before the intervention to immediately after the intervention ]
    Mean power output measured during a 40-minute all-out cycling test

  2. Performance during a 15-minute all-out cycling test [ Time Frame: Changes from before the intervention to immediately after the intervention ]
    Mean power output measured during a 15-minute all-out cycling test


Secondary Outcome Measures :
  1. Total RNA in muscle tissue (before intervention) [ Time Frame: Before the intervention ]
    Total RNA content in m. vastus lateralis (ug per mg tissue)

  2. Total RNA in muscle tissue (changes after two weeks) [ Time Frame: Changes from before the intervention to immediately after the initial two weeks of resistance training ]
    Total RNA content in m. vastus lateralis (ug per mg tissue)

  3. Muscle fiber proportions (before intervention) [ Time Frame: Before the intervention ]
    Muscle fiber proportions in m. vastus lateralis measured using immunohistochemistry

  4. Muscle fiber proportions (changes after two weeks) [ Time Frame: Changes from before the intervention to immediately after the initial two weeks of resistance training ]
    Muscle fiber proportions in m. vastus lateralis measured using immunohistochemistry

  5. Muscle fiber cross-sectional area (before intervention) [ Time Frame: Before the intervention ]
    Cross-sectional area of muscle fibres in m. vastus lateralis measured using immunohistochemistry

  6. Muscle fiber cross-sectional area (changes after two weeks) [ Time Frame: Changes from before the intervention to immediately after the initial two weeks of resistance training ]
    Cross-sectional area of muscle fibres in m. vastus lateralis measured using immunohistochemistry

  7. Myonuclear number (before intervention) [ Time Frame: Before the intervention ]
    Myonuclei per muscle fiber in m. vastus lateralis measured using immunohistochemistry

  8. Myonuclear number (changes after two weeks) [ Time Frame: Changes from before the intervention to immediately after the initial two weeks of resistance training ]
    Myonuclei per muscle fiber in m. vastus lateralis measured using immunohistochemistry

  9. rRNA expression (before intervention) [ Time Frame: Before the intervention ]
    rRNA abundances in m. vastus lateralis measured using qPCR

  10. rRNA expression (changes after two weeks) [ Time Frame: Changes from before the intervention to immediately after the initial two weeks of resistance training ]
    rRNA abundances in m. vastus lateralis measured using qPCR

  11. mRNA expression (before intervention) [ Time Frame: Before the intervention ]
    mRNA abundances in m. vastus lateralis measured using qPCR

  12. mRNA expression (changes after two weeks) [ Time Frame: Changes from before the intervention to immediately after the initial two weeks of resistance training ]
    mRNA abundances in m. vastus lateralis measured using qPCR

  13. Maximal concentric force production [ Time Frame: Changes from before the intervention to immediately after the intervention ]
    Maximal concentric force production measured using a seated leg press test

  14. Sprint performance [ Time Frame: Changes from before the intervention to immediately after the intervention ]
    Mean power output measured during a 10-second all-out cycling sprint

  15. Maximal oxygen consumption [ Time Frame: Changes from before the intervention to immediately after the intervention ]
    Maximal oxygen consumption measured during an incremental cycling exercise test to exhaustion

  16. Maximal aerobic power output [ Time Frame: Changes from before the intervention to immediately after the intervention ]
    Maximal aerobic power output measured as mean power output during the last minute of an incremental cycling exercise test to exhaustion

  17. Power output at lactate threshold [ Time Frame: Changes from before the intervention to immediately after the intervention ]
    Power output at 4 mmol blood lactate concentration measured during an incremental cycling exercise test (with 5 minute steps)

  18. Gross efficiency [ Time Frame: Changes from before the intervention to immediately after the intervention ]
    Contribution of total energy turnover to power output in the fresh and fatigued state

  19. Fractional utilization of VO2max (incremental test) [ Time Frame: Changes from before the intervention to immediately after the intervention ]
    Fractional utilization of VO2max measured at 4 mmol blood lactate concentrations measured during an incremental cycling exercise test (with 5 minute steps)

  20. Fractional utilization of VO2max (15-minute performance test) [ Time Frame: Changes from before the intervention to immediately after the intervention ]
    Fractional utilization of VO2max measured during a 15-minute performance test

  21. Hemoglobin mass [ Time Frame: Changes from before the intervention to immediately after the intervention ]
    Hemoglobin mass measured using CO rebreathing (g)

  22. Blood volume [ Time Frame: Changes from before the intervention to immediately after the intervention ]
    Blood volume measured using CO rebreathing

  23. Plasma volume [ Time Frame: Changes from before the intervention to immediately after the intervention ]
    Plasma volume measured using CO rebreathing

  24. Red blood cell volume [ Time Frame: Changes from before the intervention to immediately after the intervention ]
    Red blood cell volume measured using CO rebreathing

  25. Hematocrit [ Time Frame: Changes from before the intervention to immediately after the intervention ]
    Hematocrit measured using centrifugation


Other Outcome Measures:
  1. Endurance training volume [ Time Frame: Throughout study completion (daily), an average of ten weeks ]
    Self-reported endurance training volume measured as time-spent in different exercise intensity zones

  2. Resistance training volume [ Time Frame: Throughout study completion (daily), an average of ten weeks ]
    Self-reported resistance training volume measured as load x repetitions



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion criteria:

  • VO2max > 65 ml/kg/min (male participants)
  • VO2max > 50 ml/kg/min (female participants)
  • >7 hours of endurance training per week for the 6 months leading up to the study

Exclusion criteria:

- having conducted regular resistance training for the last 6 months leading up to the study


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04637178


Contacts
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Contact: Bent R Rønnestad, PhD 95169656 bent.ronnestad@inn.no
Contact: Stian Ellefsen, PhD +4797666521 stian.ellefsen@inn.no

Locations
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Norway
Inland Norway University of Applied Sciences Recruiting
Lillehammer, Inland Norway, Norway, 2613
Contact: Anne S Lofthus    40854711 ext +47    anne.lofthus@inn.no   
Sub-Investigator: Bent R Rønnestad, PhD         
Sub-Investigator: Stian Ellefsen, PhD         
Sponsors and Collaborators
Inland Norway University of Applied Sciences
Investigators
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Study Chair: Anne S Lofthus Research Administrator
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Responsible Party: Inland Norway University of Applied Sciences
ClinicalTrials.gov Identifier: NCT04637178    
Other Study ID Numbers: Trainome 2020#025-2
First Posted: November 19, 2020    Key Record Dates
Last Update Posted: November 19, 2020
Last Verified: November 2020

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Inland Norway University of Applied Sciences:
Cycling
Endurance performance
Skeletal muscle biology
Individualization
Muscle fiber type proportions
Ribosomal RNA