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Choice Switching and Autism

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ClinicalTrials.gov Identifier: NCT04631432
Recruitment Status : Recruiting
First Posted : November 17, 2020
Last Update Posted : April 1, 2021
Sponsor:
Information provided by (Responsible Party):
Prof. Eldad Yechiam, Technion, Israel Institute of Technology

Brief Summary:
The study aims to replicate and clarify a recently observed phenomenon whereby individuals with Autism Spectrum Disorder (ASD) switch between options in a repeated task to a greater extent than healthy controls do. In a meta-analysis a large effect size was found (.37) yet because the effect was noisy in different studies it was not statistically significant. The investigators seek to first examine a very large population through an Internet mediated platform. The sample size will be about the size of all of the previous studies that examined this issue together. Secondly, the investigators wish to understand the discrepancy between this choice switching phenomenon and the recorded tendency of ASD individuals to avoid changing choices. First, the investigators will administer the task in which the effect was found (the Iowa Gambling task) for a longer duration than previously and evaluate whether ASD individuals show increased choice switching in the first blocks of trials but reduced switching following more experience. Secondly, the investigators will administer an additional block of trials without feedback in which participants will not be able to go through a learning process. The investigators predict that this will reduce (and possible flip) the tendency of individuals with ASD to switch choices more often.

Condition or disease Intervention/treatment
Autism Spectrum Disorder (ASD) Diagnostic Test: Pre-screening Behavioral: Task session

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Study Type : Observational
Estimated Enrollment : 400 participants
Observational Model: Case-Control
Time Perspective: Cross-Sectional
Official Title: Choice Switching and Autism
Actual Study Start Date : January 1, 2021
Estimated Primary Completion Date : October 2021
Estimated Study Completion Date : October 2021

Resource links provided by the National Library of Medicine


Group/Cohort Intervention/treatment
Study participation
All participants will complete the same protocol
Diagnostic Test: Pre-screening
Document upload of Autism diagnosis certificate. Participants can request to show their certificate via a Zoom meeting with the researcher instead of uploading it.

Behavioral: Task session

The Iowa Gambling task- four decks of cards on the computer screen. Each card yields a reward, but might also yield a loss. In each trial, the participant selects a card. Consequently, the card is exposed, displaying the gain and the loss for that trial. Through contingent feedback, participants are expected to learn that some deck are better than others.The task will include 120 trials.

Block of trials without feedback- four decks of cards on the computer screen. Each card yields a reward, but might also yield a loss. In each trial, the participant selects a card. Consequently, the card is exposed, but the gain and the loss for that trial are not displayed. The task will include 30 trials.

Social Responsiveness Scale, 2nd Edition (SRS-2; adult-self report):(Constantino & Gruber, 2012) The brief autism quotient scale:(AQ10; Baron-Cohen et al., 2001) Brief intelligence test (Similarities-MAB + Raven Set 1)





Primary Outcome Measures :
  1. Mean run size [ Time Frame: Through study completion, an average of 1 year ]
    Number of consecutive selections from the same deck (across trials and in different blocks).

  2. Advantageous selections [ Time Frame: Through study completion, an average of 1 year ]
    Percentage of advantageous selections(across trials and in different blocks).



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Gender Based Eligibility:   Yes
Gender Eligibility Description:   Same proportion of males and females from the two groups.
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
We will recruit participants using websites for recruiting experimental participants worldwide.
Criteria

Inclusion Criteria:

  • ASD group - Diagnosed with ASD
  • Control - No ASD diagnosis

Exclusion Criteria:

  • Demographics: Under 18 years of age.
  • Mental health: self reported brain injury and neurological disorder (besides autism)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04631432


Contacts
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Contact: Eldad Yechiam, Professor +97248294420 yeldad@ie.technion.ac.il

Locations
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Israel
Technion, Israel Institute of Technology Recruiting
Haifa, Israel
Contact: Eldad Yechiam, PhD    972-4-8294420    yeldad@ie.technion.ac.il   
Sponsors and Collaborators
Technion, Israel Institute of Technology
Investigators
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Study Director: Dana Zeif, MSc Technion, Israel Institute of Technology
Study Director: Ofir Yakobi, PhD University of Waterloo
Principal Investigator: Eldad Yechaim, Professor Technion, Israel Institute of Technology
Study Data/Documents: Statistical Analysis Plan  This link exits the ClinicalTrials.gov site

Publications:
Ozonoff S. Reliability and validity of the Wisconsin card sorting test in studies of autism. Neuropsychology. 1995;9(4):491.
Gaeth GJ, Levin IP, Jain G, Data EV. Toward understanding everyday decision making by adults across the autism spectrum. Judgment and Decision Making. 2016 Nov 1;11(6):537.

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Responsible Party: Prof. Eldad Yechiam, Professor, Technion, Israel Institute of Technology
ClinicalTrials.gov Identifier: NCT04631432    
Other Study ID Numbers: 109171
Technion institute 109171 ( Other Grant/Funding Number: Technion - Israel Institute of Technology )
First Posted: November 17, 2020    Key Record Dates
Last Update Posted: April 1, 2021
Last Verified: March 2021
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Prof. Eldad Yechiam, Technion, Israel Institute of Technology:
Autism Spectrum Disorder
Decision Making
Additional relevant MeSH terms:
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Autistic Disorder
Autism Spectrum Disorder
Child Development Disorders, Pervasive
Neurodevelopmental Disorders
Mental Disorders